MMP10
Template:PBB Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an enzyme that in humans is encoded by the MMP10 gene.[1][2]
Function
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[3]
MMP10 has been linked to cancer stem cell vitality and metastasis [4]
References
- ^ Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R (July 1988). "The collagenase gene family in humans consists of at least four members". Biochem. J. 253 (1): 187–92. PMC 1149273. PMID 2844164.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Jung JY, Warter S, Rumpler Y (1990). "Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization". Ann. Genet. 33 (1): 21–3. PMID 2369069.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: MMP10 matrix metallopeptidase 10 (stromelysin 2)".
- ^ http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0035040?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+plosone%2FBiochemistry+%28PLoS+ONE+Alerts%3A+Biochemistry%29
Further reading
External links
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