Imidazolate

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Structures	Swiss-model
Domains	InterPro

SOD1, soluble
SOD1, soluble
	In the human SOD1 enzyme (rainbow-color N-terminus = blue, C-terminus = red), the copper (orange sphere) and zinc (grey sphere) centers are bridged by imidazolate.
Identifiers
Symbol	SOD1
Alt. symbols	ALS, ALS1
NCBI gene	6647
HGNC	11179
OMIM	147450
RefSeq	NM_000454
UniProt	P00441
Other data
EC number	1.15.1.1
Locus	Chr. 21 q22.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Imidazolate (C₃H₃N₂^-) is the conjugate base of imidazole. It is a nucleophile and a strong base. The free anion has C_2v symmetry. It is prepared by deprotonation of imidazole C₃H₃N₂H) with strong base.

Occurrence

Imidazolate is a common bridging ligand in coordination chemistry. In the Zeolitic imidazolate frameworks, the metals are interconnected via imidazolates.^[1]^[2] In the enzyme superoxide dismutase, imidazolate links a Cu and Zn centers.

References

^ Phan, A.; Doonan, C. J.; Uribe-Romo, F. J.; Knobler, C. B.; O'Keeffe, M.; Yaghi, O. M., "Synthesis, Structure, and Carbon Dioxide Capture Properties of Zeolitic Imidazolate Frameworks", Acc. Chem. Res. 2010, 43, 58-67. doi:10.1021/ar900116g
^ Zhang, J.-P.; Zhang, Y.-B.; Lin, J.-B.; Chen, X.-M., "Metal Azolate Frameworks: From Crystal Engineering to Functional Materials", Chem. Rev. 2012, vol. 112, pp. 1001-1033. doi:10.1021/cr200139g
^ PDB: 3CQQ; Cao X, Antonyuk SV, Seetharaman SV, Whitson LJ, Taylor AB, Holloway SP, Strange RW, Doucette PA, Valentine JS, Tiwari A, Hayward LJ, Padua S, Cohlberg JA, Hasnain SS, Hart PJ (June 2008). "Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis". J. Biol. Chem. 283 (23): 16169–77. doi:10.1074/jbc.M801522200. PMC 2414278. PMID 18378676.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1] Phan, A.; Doonan, C. J.; Uribe-Romo, F. J.; Knobler, C. B.; O'Keeffe, M.; Yaghi, O. M., "Synthesis, Structure, and Carbon Dioxide Capture Properties of Zeolitic Imidazolate Frameworks", Acc. Chem. Res. 2010, 43, 58-67. doi:10.1021/ar900116g

[2] Zhang, J.-P.; Zhang, Y.-B.; Lin, J.-B.; Chen, X.-M., "Metal Azolate Frameworks: From Crystal Engineering to Functional Materials", Chem. Rev. 2012, vol. 112, pp. 1001-1033. doi:10.1021/cr200139g

[pmid-3] PDB: 3CQQ; Cao X, Antonyuk SV, Seetharaman SV, Whitson LJ, Taylor AB, Holloway SP, Strange RW, Doucette PA, Valentine JS, Tiwari A, Hayward LJ, Padua S, Cohlberg JA, Hasnain SS, Hart PJ (June 2008). "Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis". J. Biol. Chem. 283 (23): 16169–77. doi:10.1074/jbc.M801522200. PMC 2414278. PMID 18378676.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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