OpenPHACTS
| Formation | 2011 |
|---|---|
| Type | Public–private partnership |
| Purpose | Semantic interoperability for drug discovery through Open innovation |
| Membership | 27 member organisations |
Key people | |
| Website |
Open PHACTS (Open Pharmacological Concept Triple Store) is public–private partnership between academia, publishers, enterprises, pharmaceutical companies and other organisations working to enable better, cheaper and faster drug discovery.[1][2][3][4] It has been funded by the Innovative Medicines Initiative,[5] selected as part of three projects to "design methods for common standards and sharing of data for more efficient drug development and patient treatment in the future".[6][7]
Partnerships
A total of 27 partners are currently involved including:
- Academia: Maastricht University, University of Santiago de Compostela, University of Vienna, University of Manchester, University of Bonn, Swiss Institute of Bioinformatics, European Bioinformatics Institute, Vrije Universiteit of Amsterdam, Technical University of Denmark, University of Hamburg
- Pharmaceutical companies: Pfizer, Merck KGaA, Eli Lilly and Company, Novartis, GlaxoSmithKline, AstraZeneca
- Other companies: ChemSpider, Accelrys, Eagle Genomics , Entagen
- Publishers: Royal Society of Chemistry, Thomson Reuters
Drug discovery
The Open Pharmacological Space created by the consortium is intended to support open innovation and in-house non-public drug discovery research[8] by removing bottlenecks in drug development.[9][10] Resources from the project are publicly available on GitHub.[11]
To reduce the barriers to drug discovery in industry, academia and for small businesses, the Open PHACTS consortium is building the Open PHACTS Discovery Platform. This platform is freely available, integrating pharmacological data from a variety of information resources and providing tools and services to question this integrated data to support pharmacological research.
References
- ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/j.drudis.2012.05.016, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with
|doi=10.1016/j.drudis.2012.05.016instead. - ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1002/minf.201280004, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with
|doi=10.1002/minf.201280004instead. - ^ Gray, Alasdair J.G.; Groth, Paul; Loizou, Antonis; Askjaer, Sune; Brenninkmeijer, Christian; Burger, Kees; Chichester, Christine; Evelo, Chris T.; Goble, Carole; Harland, Lee; Pettifer, Steve; Thompson, Mark; Waagmeester, Andra; Williams, Antony John (2014). "Applying linked data approaches to pharmacology: Architectural decisions and implementation". Semantic Web. 5 (2): 101–113. doi:10.3233/SW-2012-0088.
- ^ Ciccarese, P; Soiland-Reyes, S; Belhajjame, K; Gray, A. J.; Goble, C; Clark, T (2013). "PAV ontology: Provenance, authoring and versioning". Journal of Biomedical Semantics. 4 (1): 37. doi:10.1186/2041-1480-4-37. PMID 24267948.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ "Open PHACTS at IMI - The Innovative Medicines Initiative".
- ^ Watson, R. (2011). "Europe provides €172m for research into innovative medicines". BMJ. 342: d1577. doi:10.1136/bmj.d1577. PMID 21393337.
- ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi: 10.1007/978-3-642-41338-4_5, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with
|doi= 10.1007/978-3-642-41338-4_5instead. - ^ Müller, S.; Weigelt, J. (2010). "Open-access public-private partnerships to enable drug discovery--new approaches". IDrugs : the investigational drugs journal. 13 (3): 175–180. PMID 20191434.
- ^ Dalgleish, R.; Molero, E.; Kidd, R.; Jansen, M.; Past, D.; Robl, A.; Mons, B.; Diaz, C.; Mons, A.; Brookes, A. J. (2012). "Solving bottlenecks in data sharing in the life sciences". Human Mutation. 33 (10): 1494–1496. doi:10.1002/humu.22123. PMID 22623360.
- ^ Mons, B.; Van Haagen, H.; Chichester, C.; Hoen, P. B. 'T.; Den Dunnen, J. T.; Van Ommen, G.; Van Mulligen, E.; Singh, B.; Hooft, R.; Roos, M.; Hammond, J.; Kiesel, B.; Giardine, B.; Velterop, J.; Groth, P.; Schultes, E. (2011). "The value of data". Nature Genetics. 43 (4): 281–283. doi:10.1038/ng0411-281. PMID 21445068.
- ^ "Open PHACTS on GitHub". Retrieved 2012-07-10.