Microprocessor complex subunit DGCR8
Template:PBB DGCR8 (DiGeorge syndrome chromosomal region 8) is a protein that in humans is encoded by the DGCR8 gene.[1] In other animals, particularly the common model organisms Drosophila melanogaster and Caenorhabditis elegans, the protein is known as Pasha (partner of Drosha).[2] It is a required component of the RNA interference pathway.
The protein is localized to the cell nucleus and is required for microRNA (miRNA) processing. It binds to Drosha, an RNase III enzyme, to form the Microprocessor complex that cleaves a primary transcript known as pri-miRNA to a characteristic stem-loop structure known as a pre-miRNA, which is then further processed to miRNA fragments by the enzyme Dicer. Pasha contains an RNA-binding domain and is thought to bind pri-miRNA to stabilize it for processing by Drosha.[3]
References
- ^ "Entrez Gene: DGCR8 DiGeorge syndrome critical region gene 8".
- ^ Denli, AM; Tops, BB; Plasterk, RH; Ketting, RF; Hannon, GJ (11 November 2004). "Processing of primary microRNAs by the Microprocessor complex". Nature. 432 (7014): 231–5. PMID 15531879.
- ^ Yeom, KH; Lee, Y; Han, J; Suh, MR; Kim, VN (2006). "Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing". Nucleic acids research. 34 (16): 4622–9. doi:10.1093/nar/gkl458. PMC 1636349. PMID 16963499.
Further reading
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