Talk:Expanded genetic code

A fact from Expanded genetic code appeared on Wikipedia's Main Page in the Did you know column on 24 October 2009 (check views). The text of the entry was as follows:

Did you know
- ... that several groups have managed to add non-natural bases to DNA, while others have added non-natural amino acids into the genetic code?
A record of the entry may be seen at Wikipedia:Recent additions/2009/October.

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Untitled

I have copied part of this into genetic code so this atm is repeated. but I will expand on it soon. so plz do not delete. --Squidonius (talk) 21:14, 13 October 2009 (UTC)[reply]

expanded (forgot to log in though)--Squidonius (talk) 12:50, 16 October 2009 (UTC)[reply]

Removed for lack of clarity

Removed "from the existing 20 to a theoretically possible 172," because it is not clear what the 20 refers to (though it probably means the 20 amino acids expressed by the standard code) or where the theoretically possible 172 comes from. If the same redundancy as the current codes were used an expansion of about a factor of four might be expected, for example. It is probable that the 172 is based on expanding the existing 64 codes to 216 giving an additional 152 codes, which if they were mapped uniquely to new AAs would yield a total of 172 AAs. It is not clear, however, with the massive re-engineering of the transcription machinery required, why the redundancy in the existing code need be preserved, nor indeed the coding length of 3. All the best: Rich Farmbrough, 01:31, 28 August 2014 (UTC).

Peter G. Schultz

The article is incomplete because it fails to mention Professor Peter G. Schultz, who is the main researcher and leading expert on expanded genetic codes. He first developed the method of screening mutant libraries for artificial AARSs which charge nonsense anti-codon-containing tRNAs with unnatural amino acids, allowing the expansion of genetic codes of many organisms. Goblinshark17 (talk) 06:46, 3 October 2014 (UTC)[reply]