OpenPHACTS

Open PHACTS
Formation	2011
Type	Public–private partnership
Purpose	Semantic interoperability for drug discovery through Open innovation
Membership	27 member organisations
Key people	Antony John Williams; Carole Goble; Barend Mons; Gerhard Ecker;
Website	www.openphacts.org; github.com/openphacts;

Open PHACTS (Open Pharmacological Concept Triple Store) is public–private partnership between academia, publishers, enterprises, pharmaceutical companies and other organisations working to enable better, cheaper and faster drug discovery.^[1]^[2]^[3]^[4] It has been funded under a European grant from the Innovative Medicines Initiative,^[5] selected as part of three projects to "design methods for common standards and sharing of data for more efficient drug development and patient treatment in the future".^[6]^[7]

Partnerships

A total of 27 partners are currently involved including:

Academia: Maastricht University, University of Santiago de Compostela, University of Vienna, University of Manchester, University of Bonn, Swiss Institute of Bioinformatics, European Bioinformatics Institute, Vrije Universiteit of Amsterdam, Technical University of Denmark, University of Hamburg
Pharmaceutical companies: Pfizer, Merck KGaA, Eli Lilly and Company, Novartis, GlaxoSmithKline, AstraZeneca
Other companies: ChemSpider, Accelrys, Eagle Genomics , Entagen
Publishers: Royal Society of Chemistry, Thomson Reuters

Drug discovery

The Open Pharmacological Space created by the consortium is intended to support open innovation and in-house non-public drug discovery research^[8] by removing bottlenecks in drug development.^[9]^[10] Resources from the project are publicly available on GitHub.^[11]

To reduce the barriers to drug discovery in industry, academia and for small businesses, the Open PHACTS consortium is building the Open PHACTS Discovery Platform. This platform is freely available, integrating pharmacological data from a variety of information resources and providing tools and services to question this integrated data to support pharmacological research.

References

^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/j.drudis.2012.05.016, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1016/j.drudis.2012.05.016 instead.
^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1002/minf.201280004, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1002/minf.201280004 instead.
^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.3233/SW-2012-0088, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.3233/SW-2012-0088 instead.
^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1186/2041-1480-4-37, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1186/2041-1480-4-37 instead.
^ "Open PHACTS at IMI - The Innovative Medicines Initiative".
^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1136/bmj.d1577, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1136/bmj.d1577 instead.
^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi: 10.1007/978-3-642-41338-4_5, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi= 10.1007/978-3-642-41338-4_5 instead.
^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20191434, please use {{cite journal}} with |pmid=20191434 instead.
^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22623360, please use {{cite journal}} with |pmid=22623360 instead.
^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1038/ng0411-281, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1038/ng0411-281 instead.
^ "Open PHACTS on GitHub". Retrieved 2012-07-10.

[1] Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/j.drudis.2012.05.016, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1016/j.drudis.2012.05.016 instead.

[2] Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1002/minf.201280004, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1002/minf.201280004 instead.

[3] Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.3233/SW-2012-0088, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.3233/SW-2012-0088 instead.

[4] Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1186/2041-1480-4-37, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1186/2041-1480-4-37 instead.

[5] "Open PHACTS at IMI - The Innovative Medicines Initiative".

[6] Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1136/bmj.d1577, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1136/bmj.d1577 instead.

[7] Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi: 10.1007/978-3-642-41338-4_5, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi= 10.1007/978-3-642-41338-4_5 instead.

[8] Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20191434, please use {{cite journal}} with |pmid=20191434 instead.

[9] Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22623360, please use {{cite journal}} with |pmid=22623360 instead.

[10] Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1038/ng0411-281, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1038/ng0411-281 instead.

[11] "Open PHACTS on GitHub". Retrieved 2012-07-10.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]