Roderick Lim
Roderick Lim | |
|---|---|
 Roderick Lim (2014) | |
| Born | 16 October 1974 |
| Nationality | Singaporean |
| Scientific career | |
| Fields | Nanophysicist |
| Institutions | University of North Carolina at Chapel Hill, National University of Singapore , M.E. Mueller Institute for Structural Biology , Biozentrum University of Basel |
Roderick Lim (born 16 October 1974 in Singapore) is a Singaporean nano- and biophysicist at the Biozentrum of the University of Basel, Switzerland.
Life
Lim studied physics at the University of North Carolina at Chapel Hill. In 2003 he obtained his PhD from the National University of Singapore for research carried out at the Institute of Materials Research and Engineering.[1] This was followed by postdoctoral work at the M.E. Mueller Institute for Structural Biology at the Biozentrum until 2008. In 2009, he was appointed Argovia Professor for nanobiology at the Biozentrum and the Swiss Nanoscience Institute, where he received tenure in early 2014.[2]
Work
Lim is interested in nucleocytoplasmic transport regulation, its impact on cellular function, and how this phenomenon can be leveraged towards bio-inspired applications. He studies how karyopherin receptors facilitate this highly rapid and selective process through nuclear pore complexes (NPCs). Lim combines biophysical, nanotechnological, and cellular approaches to unravel the emergent physical principles that underlie biological function and then verify the results in biomimetic systems. His key contributions include a karyopherin-centric model of the NPC and the discovery of two-dimensional transport control in artificial systems. Of late, he has gravitated towards mechanobiology, in particular cell motility and cancer progression. Lim is a co-inventor of ARTIDIS ("Automated and Reliable Tissue Diagnostics"), an atomic force microscope-based innovation for cancer diagnosis.[3]
Awards and honors
Notable publications
Full publication list[4]
- K.D. Schleicher, S.L. Dettmer, L.E. Kapinos, S. Pagliara, U.F. Keyser, S. Jeney and R.Y.H. Lim*. Selective Transport Control on Molecular Velcro made from Intrinsically Disordered Proteins. Nature Nanotechnology, advance online publication. DOI: 10.1038/NNANO.2014.103 PMID 24929341
- M. Plodinec, M. Loparic, C.A. Monnier, E.C. Obermann, R. Zanetti-Dallenbach, P. Oertle, J.T. Hyotyla, U. Aebi, M. Bentires-Alj, R.Y.H. Lim* and C-A. Schoenenberger, The Nanomechanical Signature of Breast Cancer, Nature Nanotechnology 7 757 (2012) PMID 23085644
- S.W. Kowalczyk, L.E. Kapinos, T. Magalhães, P. van Nies, R.Y.H. Lim*, and C. Dekker*, Single-Molecule Transport Across an Individual Biomimetic Nuclear Pore Complex, Nature Nanotechnology 6, 433 (2011) PMID 21685911
- R.Y.H. Lim*, B. Fahrenkrog, J. Koser, K. Schwarz-Herion, J. Deng, and U. Aebi, Nanomechanical Basis of Selective Gating by the Nuclear Pore Complex, Science 318 640 (2007) PMID 17916694
- R.Y.H. Lim*, N.P. Huang, J. Koser, J. Deng, K.H.A. Lau, K. Schwarz-Herion, B. Fahrenkrog, and U. Aebi, Flexible Phenylalanine-Glycine Nucleoporins as Entropic Barriers to Nucleocytoplasmic Transport. PNAS 103 9512 (2006) PMID 16769882
References
- ^ "Ph.D Theses National University of Singapore (NUS)". nus.edu.sg. Retrieved 2014-09-02.
- ^ "Curriculum Vitae". Biozentrum.unibas.ch. Retrieved 2014-09-02.
- ^ "Hard shell and soft core". nanoscience.ch. 2012-12-10. Retrieved 2014-09-02.
- ^ "Publication list". Biozentrum.unibas.ch. Retrieved 2014-09-15.