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Roderick Lim

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Roderick Lim
Roderick Lim (2014)
Born (1974-10-16) 16 October 1974 (age 50)
Singapore
NationalitySingaporean
Scientific career
FieldsNanophysicist
InstitutionsUniversity of North Carolina at Chapel Hill, National University of Singapore , M.E. Mueller Institute for Structural Biology , Biozentrum University of Basel

Roderick Lim (born 16 October 1974 in Singapore) is a Singaporean nano- and biophysicist at the Biozentrum of the University of Basel, Switzerland.

Life

Roderick Lim studied physics at the University of North Carolina at Chapel Hill, USA. In 2003 he obtained his PhD from the National University of Singapore (NUS) for research carried out at the Institute of Materials Research and Engineering (IMRE).[1] This was followed by postdoctoral work at the M.E. Mueller Institute for Structural Biology at the Biozentrum until 2008. In 2009, he was appointed Argovia Professor for Nanobiology at the Biozentrum and the Swiss Nanoscience Institute, University of Basel, where he received tenure in early 2014.[2]

Work

Roderick Lim is interested in nucleocytoplasmic transport regulation, its impact on cellular function, and how this fascinating phenomenon can be leveraged towards bio-inspired applications. He studies how karyopherin receptors facilitate this highly rapid and selective process through nuclear pore complexes (NPCs). Lim combines biophysical, nanotechnological and cellular approaches to unravel the emergent physical principles that underlie biological function and then to “ground truth” the results in biomimetic systems. His key contributions include a karyopherin-centric model of the NPC and the discovery of two-dimensional transport control in artificial systems. Of late, he has gravitated towards mechanobiology, in particular cell motility and cancer progression. Lim is a co-inventor of ARTIDIS® “Automated and Reliable Tissue Diagnostics”, an atomic force microscope-based innovation for cancer diagnosis.[3]

Awards and honors

  • 2008 Pierre-Gilles de Gennes Prize
  • 2004 International Fellowship from the Agency of Science, Technology and Research (A*STAR, Singapore)

Notable publications

Full publication list[4]

  • K.D. Schleicher, S.L. Dettmer, L.E. Kapinos, S. Pagliara, U.F. Keyser, S. Jeney and R.Y.H. Lim*. Selective Transport Control on Molecular Velcro made from Intrinsically Disordered Proteins. Nature Nanotechnology, advance online publication. DOI: 10.1038/NNANO.2014.103 PMID 24929341
  • L.E. Kapinos, R.L. Schoch, R.S. Wagner, K.D. Schleicher and R.Y.H Lim*. Karyopherin-centric Control of Nuclear Pores based on Molecular Occupancy and Kinetic Analysis of Multivalent Binding with FG-Nucleoporins. Biophys. J. 106 1751 (2014) PMID 24739174
  • M. Plodinec, M. Loparic, C.A. Monnier, E.C. Obermann, R. Zanetti-Dallenbach, P. Oertle, J.T. Hyotyla, U. Aebi, M. Bentires-Alj, R.Y.H. Lim* and C-A. Schoenenberger, The Nanomechanical Signature of Breast Cancer, Nature Nanotechnology 7 757 (2012) PMID 23085644
  • R.L. Schoch, L.E. Kapinos, and R.Y.H. Lim*, Nuclear Transport Receptor Binding Avidity Triggers a Self-Healing Collapse Transition in FG-Nucleoporin Molecular Brushes, PNAS 109 16911 (2012) PMID 23043112
  • S.W. Kowalczyk, L.E. Kapinos, T. Magalhães, P. van Nies, R.Y.H. Lim*, and C. Dekker*, Single-Molecule Transport Across an Individual Biomimetic Nuclear Pore Complex, Nature Nanotechnology 6, 433 (2011) PMID 21685911
  • R.Y.H. Lim*, B. Fahrenkrog, J. Koser, K. Schwarz-Herion, J. Deng, and U. Aebi, Nanomechanical Basis of Selective Gating by the Nuclear Pore Complex, Science 318 640 (2007) PMID 17916694
  • R.Y.H. Lim*, N.P. Huang, J. Koser, J. Deng, K.H.A. Lau, K. Schwarz-Herion, B. Fahrenkrog, and U. Aebi, Flexible Phenylalanine-Glycine Nucleoporins as Entropic Barriers to Nucleocytoplasmic Transport. PNAS 103 9512 (2006) PMID 16769882
  • R. Lim and S.J. O'Shea, Solvation Forces in Branched Molecular Liquids, Physical Review Letters 88 246101 (2002) PMID 12059317

References

  1. ^ "Ph.D Theses National University of Singapore (NUS)". nus.edu.sg. Retrieved 2014-09-02.
  2. ^ "Curriculum Vitae". Biozentrum.unibas.ch. Retrieved 2014-09-02.
  3. ^ "Hard shell and soft core". nanoscience.ch. 2012-12-10. Retrieved 2014-09-02.
  4. ^ "Publication list". Biozentrum.unibas.ch. Retrieved 2014-09-02.

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