Toxin and Toxin-Target Database
| Content | |
|---|---|
| Description | Toxin and toxin target database |
| Data types captured | Small molecule poisons, toxic compounds and toxins, chemical structures, toxic compound descriptions, chemical taxonomy, toxin targets and transporters, target protein sequences, mechanisms of action, lethal doses, chemical properties, nomenclature, synonyms |
| Contact | |
| Research center | University of Alberta and The Metabolomics Innovation Centre |
| Laboratory | Dr. David Wishart |
| Primary citation | [1] |
| Access | |
| Website | http://www.t3db.org |
| Download URL | http://www.t3db.org/downloads |
| Miscellaneous | |
| Data release frequency | Every 3-4 years with periodic corrections and updates |
| Curation policy | Manually curated |
The Toxin and Toxin-Target Database (T3DB)[1] is a comprehensive, high-quality, freely accessible, online database of common toxic substances and their protein/DNA or organ targets. The database currently houses 3,053 toxic compounds or poisons described by 32,276 synonyms. This list includes common pollutants, pesticides, drugs, and food toxins. These toxic substances are linked to 1,670 corresponding protein/DNA target records. In total there are 37,084 toxic substance-toxin target associations. Each toxic compound record (ToxCard) in T3DB contains nearly 60 data fields and holds information such as chemical properties and descriptors, mechanisms of action, toxicity or lethal-dose values, molecular and cellular interactions, and medical (symptom and treatment) information. This information has been extracted from over 5,454 sources, which include other databases, government documents, books, and scientific literature.
The primary focus of the T3DB is on providing mechanisms of toxicity and identifying target proteins for common toxic substances. While a number of other toxic compound databases do exist, their emphasis is on covering large numbers of chemical compounds that are almost never seen outside a chemical laboratory. T3DB attempts to capture data on only those toxic substances that are abundant or in widespread use and have been detected or measured in humans. T3DB is fully searchable and supports extensive text, sequence, chemical structure, and relational query searches. It is both modelled after and closely linked to the Human Metabolome Database (HMDB) and DrugBank. Potential applications of T3DB include metabolomics and environmental exposure studies, toxic compound metabolism prediction, toxin/drug interaction prediction, and general toxic substance awareness.
Scope and Access
All data in T3DB is non-proprietary or is derived from a non-proprietary source. It is freely accessible and available to anyone. In addition, nearly every data item is fully traceable and explicitly referenced to the original source. T3DB data is available through a public web interface and downloads.
References
- ^ a b Lim, E (Jan 2010). "T3DB: a comprehensively annotated database of common toxins and their targets". Nucleic Acids Research. 38 (Database issue): D781-6. doi:10.1093/nar/gkp934. PMC 2808899. PMID 19897546.
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