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Toxin and Toxin-Target Database

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T3DB
Content
DescriptionToxin and toxin target database
Data types
captured		Small molecule poisons, toxic compounds and toxins, chemical structures, toxic compound descriptions, chemical taxonomy, toxin targets and transporters, target protein sequences, mechanisms of action, lethal doses, chemical properties, nomenclature, synonyms
Contact
Research centerUniversity of Alberta and The Metabolomics Innovation Centre
LaboratoryDr. David Wishart
Primary citation[1]
Access
Websitehttp://www.t3db.org
Download URLhttp://www.t3db.org/downloads
Miscellaneous
Data release
frequency		Every 3-4 years with periodic corrections and updates
Curation policyManually curated

The Toxin and Toxin-Target Database (T3DB)[1] is a comprehensive online database of over 2900 toxins and over 1300 corresponding toxin targets. These toxins include pollutants, food toxins, drugs, and pesticides.[2] T3DB was created by researchers at the University of Alberta, under the leadership of Dr. David Wishart.

Each toxin is displayed as a "ToxCard" with over 50 data fields including toxicity values, medical information, molecular and cellular interactions, and chemical properties and descriptors. The Wishart Research Group[3] extracted information from over 5600 sources to build this database. The various sources include the scientific literature, books, government documents, and numerous external databases (such as PubChem, UniProt, PubMed, DrugBank, Human Metabolome Database (HMDB), NIST Chemistry WebBook, KEGG, NCI Database Browser, PharmGKB, Food and Drug Administration, ChEBI, and ChemExper). T3DB enables users to discover mechanisms of toxicity for various toxins as well as the target proteins with which each toxin interacts. Researchers can use T3DB to predict toxin-drug interactions, predict toxin metabolism, and to increase their general awareness of toxins. Much of T3DB's content is downloadable[4] including its descriptive fields, tables, and images.[5]

T3DB is part of a suite of metabolomics databases that also includes HMDB, DrugBank, and The Small Molecule Pathway Database (SMPDB). While DrugBank includes information on 6707 drugs and 4228 non-redundant drug targets, enzymes, transporters, and carriers, HMDB houses over 7900 small molecule metabolites found in the human body. The suite is complemented by SMPDB with its pathway diagrams for more than 350 human metabolic and disease pathways.

References

  1. ^ a b Lim, E (Jan 2010). "T3DB: a comprehensively annotated database of common toxins and their targets". Nucleic Acids Research. 38 (Database issue): D781-6. doi:10.1093/nar/gkp934. PMC 2808899. PMID 19897546. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  2. ^ "Toxin and Toxin Target Database (T3DB)". Retrieved 11 January 2012.
  3. ^ "Wishart Research Group". Retrieved 17 January 2012.
  4. ^ "T3DB: Downloads". Retrieved 11 January 2012.
  5. ^ "Toxin and Toxin Target Database (T3DB)". Retrieved 11 January 2012.
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