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Flap structure-specific endonuclease 1

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Template:PBB Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.[1][2]

Template:PBB Summary

Interactions

Flap structure-specific endonuclease 1 has been shown to interact with Cyclin-dependent kinase 2,[3] EP300,[4] Werner syndrome ATP-dependent helicase,[5][6] Heterogeneous nuclear ribonucleoprotein A1,[7] Cyclin A2,[3] PCNA,[3][4][8][9][10][11][12] Bloom syndrome protein[5] and APEX1.[11]

References

  1. ^ Hiraoka LR, Harrington JJ, Gerhard DS, Lieber MR, Hsieh CL (Jul 1995). "Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human". Genomics. 25 (1): 220–5. doi:10.1016/0888-7543(95)80129-A. PMID 7774922.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ "Entrez Gene: FEN1 flap structure-specific endonuclease 1".
  3. ^ a b c Henneke, Ghislaine (Jul 2003). "Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation". Oncogene. 22 (28). England: 4301–13. doi:10.1038/sj.onc.1206606. ISSN 0950-9232. PMID 12853968. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  4. ^ a b Hasan, S (Jun 2001). "Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300". Mol. Cell. 7 (6). United States: 1221–31. doi:10.1016/S1097-2765(01)00272-6. ISSN 1097-2765. PMID 11430825. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  5. ^ a b Sharma, Sudha (Mar 2004). "Stimulation of flap endonuclease-1 by the Bloom's syndrome protein". J. Biol. Chem. 279 (11). United States: 9847–56. doi:10.1074/jbc.M309898200. ISSN 0021-9258. PMID 14688284. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  6. ^ Brosh, R M (Oct 2001). "Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity". EMBO J. 20 (20). England: 5791–801. doi:10.1093/emboj/20.20.5791. ISSN 0261-4189. PMC 125684. PMID 11598021. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  7. ^ Chai, Qing (Dec 2003). "Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in alpha-segment processing during Okazaki fragment maturation". Biochemistry. 42 (51). United States: 15045–52. doi:10.1021/bi035364t. ISSN 0006-2960. PMID 14690413. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  8. ^ Jónsson, Z O (Apr 1998). "Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen". EMBO J. 17 (8). ENGLAND: 2412–25. doi:10.1093/emboj/17.8.2412. ISSN 0261-4189. PMC 1170584. PMID 9545252. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  9. ^ Gary, R (Sep 1997). "The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21". J. Biol. Chem. 272 (39). UNITED STATES: 24522–9. doi:10.1074/jbc.272.39.24522. ISSN 0021-9258. PMID 9305916. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  10. ^ Chen, U (Oct 1996). "p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex". Proc. Natl. Acad. Sci. U.S.A. 93 (21). UNITED STATES: 11597–602. doi:10.1073/pnas.93.21.11597. ISSN 0027-8424. PMC 38103. PMID 8876181. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  11. ^ a b Dianova, I I (Oct 2001). "Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair". Biochemistry. 40 (42). United States: 12639–44. doi:10.1021/bi011117i. ISSN 0006-2960. PMID 11601988. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  12. ^ Yu, P (Jan 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. 20 (4). England: 484–9. doi:10.1038/sj.onc.1204113. ISSN 0950-9232. PMID 11313979. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)

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