Ac/Ds transposable controlling elements
In brief
The Ac/Ds transposable element system was first discovered by Barbara McClintock. The Ac Activator element is autonomous, whereas the Ds Dissociation element requires an Activator element to transpose. Ac was initially discovered as enabling a Ds element to break chromosomes. Both Ac and Ds can also insert into genes, causing mutants that may revert to normal on excision of the element[1]. These elements were first cloned By Federoff et al 1983 [2] using insertions of Ac and Ds into the well-studied Waxy(Wx1) gene.
Ac/Ds toolkits
References
- ^ McCLINTOCK, B (1950 Jun). "The origin and behavior of mutable loci in maize". Proceedings of the National Academy of Sciences of the United States of America. 36 (6): 344–55. PMID 15430309.
{{cite journal}}: Check date values in:|date=(help) - ^ Fedoroff, N (1983 Nov). "Isolation of the transposable maize controlling elements Ac and Ds". Cell. 35 (1): 235–42. PMID 6313225.
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