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Functional element SNPs database

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{{infobox biodatabase |title = FESD |logo = |description = Functional Element SNPs Database in human. |scope = |organism =Homo sapiens |center = |laboratory = |author = Hyo Jin Kang |pmid = Kang & al. (2005)Cite error: A <ref> tag is missing the closing </ref> (see the help page). The Functional Element SNPs Database (FESD) tool is designed to organize functional elements into categories in human gene regions and to output their sequences needed for genotyping experiments as well as provide a set of SNPs that lie within each region. The database defines functional elements into ten types: promoter regions, CpG islands,5' untranslated regions (5'-UTRs), translation start sites, splice sites, coding exons, introns, translation stop sites, polyadenylation signals, and 3' UTRs.[1]



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People may reference this database when haplotyping a gene or chromosome, in hopes of discovering mutations that cause disease. By utilizing the database, researchers can manually choose a group of SNPs of special interest for certain functional elements along with their corresponding sequences.[3] Also, FESD can be used to dteremine predisposition to diseases and conditions.[4] Although the database is useful, it relies on chromosome position and cytogenic banding patterns meaning it cannot recognize manually entered SNPs.


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References

  1. ^ MAH, JAMES T. L., and K. S. CHIA. "A Gentle Introduction To Snp Analysis:: Resources And Tools." Journal Of Bioinformatics & Computational Biology 5.5 (2007): 1123-1138. Academic Search Premier. Web. 9 Sept. 2013
  2. ^ GA Coetzee, et al. "Comprehensive Functional Annotation Of Seventy-One Breast Cancer Risk Loci." Plos One 8.5 (n.d.): Science Citation Index. Web. 6 Sept. 2013.
  3. ^ Chang Hsueh-Wei, et al. "Dynamic Programming For Single Nucleotide Polymorphism ID Identification In Systematic Association Studies." Kaohsiung Journal Of Medical Sciences 25.(n.d.): 165-176. ScienceDirect. Web. 9 Sept. 2013.
  4. ^ F. ( 2 ) Takagi, et al. "Novel High-Speed Droplet-Allele Specific-Polymerase Chain Reaction: Application In The Rapid Genotyping Of Single Nucleotide Polymorphisms." Clinica Chimica Acta 424.(2013): 39-46. Scopus®. Web. 18 Sept. 2013.
  5. ^ MAH, JAMES T. L., and K. S. CHIA. "A Gentle Introduction To Snp Analysis:: Resources And Tools." Journal Of Bioinformatics & Computational Biology 5.5 (2007): 1123-1138. Academic Search Premier. Web. 9
  6. ^ Haja N. Kadarmideen, et al. "Functsnp: An R Package To Link Snps To Functionalknowledge And Dbautomaker: A Suite Of Perlscripts To Build SNP Databases." BMC Bioinformatics 11.(2010): 311-319. Academic Search Premier. Web. 18 Sept. 2013.


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