Eastern seaboard
{Research|Study|Investigation|Analysis|Exploration|Homework|Investigate|Researching|Groundwork|Explore|Examine} has shown {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} {there are|you will find|you can find|you'll find|you will discover|there are actually|one can find|you can get|there can be|there is|there's} clear {differences|variations|distinctions|variances|dissimilarities|disparities|discrepancies|variation|issues|difficulties|variance} {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} distinguish {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} brains {of those|of these|of the|of people|of such|of the people|of them|these|of individuals|of|individuals} {with|along with|together with|using|having|by using|utilizing|through|with the help of|by means of|by way of} {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} {from|through|coming from|via|by|out of|with|as a result of|because of|right from|provided by} {those|individuals|these|people|all those|those people|the|the ones|some of those|many|persons} {without|with out|without having|with no|devoid of|without the need of|not having|while not|free of|lacking|with no need of} {such|this kind of|these kinds of|this sort of|these|like|these types of|this type of|these sort of|many of these|those} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains}. {Chronic|Persistent|Long-term|Continual|Serious|Constant|Severe|Recurring|Debilitating|Reoccuring|Prolonged} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} sufferers consistently {show|display|present|demonstrate|indicate|exhibit|clearly show|reveal|demonstrate to|express|illustrate} {reduced|decreased|lowered|diminished|lessened|minimized|lower|minimal|very low|cut down|cheaper} {volume|quantity|amount|size|volume level|level|sound level|quantities|fullness|volume levels|numbers} {in the|within the|inside the|from the|inside|while in the|during the|with the|on the|in your|through the} brain's gray matter, {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} cortical structures {key|crucial|important|essential|critical|major|vital|main|primary|key element|significant} {to|in order to|to be able to|for you to|to help|so that you can|that will|to help you|towards|to make sure you|to successfully} perception, movement, {memory|storage|memory space|recollection|ram|reminiscence|remembrance|random access memory|mind|recall|storage area} {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} reasoning. {Researchers|Scientists|Experts|Research workers|Analysts|Investigators|Doctors|Professionals|Specialists|Study workers|Individuals} {have|possess|have got|get|currently have|include|own|contain|now have|need|already have} {also|additionally|furthermore|in addition|likewise|as well|at the same time|moreover|even|equally|too} shown {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} {compared to|when compared with|in comparison to|in comparison with|as compared to|when compared to|as compared with|compared with|as opposed to|versus|compared to the} {healthy|wholesome|healthful|balanced|nutritious|healthy and balanced|healthier|good|strong|nourishing|in good health} {patients|individuals|sufferers|people|clients|affected individuals|men and women|persons|subjects|folks|clientele}, {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} brains {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} sufferers {are|tend to be|are usually|are generally|usually are|will be|happen to be|are actually|can be|really are|seem to be} wired differently, {in|within|inside|throughout|with|around|during|on|when it comes to|for|found in} {ways|methods|techniques|approaches|means|strategies|tactics|options|solutions|procedures|ideas} {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} {suggest|recommend|advise|propose|advocate|would suggest|highly recommend|indicate|imply|encourage|counsel} {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} physical sensations {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} emotional responses {are|tend to be|are usually|are generally|usually are|will be|happen to be|are actually|can be|really are|seem to be} bound {more|much more|a lot more|far more|additional|extra|even more|alot more|a great deal more|significantly more|way more} {tightly|firmly|securely|snugly|closely|properly|strongly|much} together.{But|However|Yet|Nevertheless|Although|Nonetheless|However ,|Though|And yet|Still|But yet} {are|tend to be|are usually|are generally|usually are|will be|happen to be|are actually|can be|really are|seem to be} {those|individuals|these|people|all those|those people|the|the ones|some of those|many|persons} brain {differences|variations|distinctions|variances|dissimilarities|disparities|discrepancies|variation|issues|difficulties|variance} {a|the|any|a new|some sort of|your|a good|an important|a fabulous|some|a real} response {to|in order to|to be able to|for you to|to help|so that you can|that will|to help you|towards|to make sure you|to successfully} {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} -- {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} brain's response {to the|towards the|for the|on the|to your|towards|into the|with the|in the|in to the|within the} {experience|encounter|expertise|knowledge|practical experience|practical knowledge|working experience|go through|adventure|feel|past experiences} {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} {months|several weeks|weeks|a few months|many weeks|many months|several months|calendar months|a long time|times|days} {or|or even|or perhaps|as well as|or maybe|and also|or simply|or possibly|and / or|and|and even} {years|many years|a long time|decades|several years|ages|yrs|quite a few years|numerous years|years and years|many} {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} physical misery? {Or|Or even|Or perhaps|As well as|Or maybe|And also|Or simply|Or possibly|And / or|And|And even} {do|perform|carry out|accomplish|complete|conduct|undertake|achieve|execute|implement|can} {those|individuals|these|people|all those|those people|the|the ones|some of those|many|persons} {differences|variations|distinctions|variances|dissimilarities|disparities|discrepancies|variation|issues|difficulties|variance} predate {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} -- nudging {what|exactly what|just what|precisely what|what exactly|just what exactly|what precisely|everything that|whatever|the things|which} {for|with regard to|regarding|pertaining to|intended for|to get|designed for|meant for|for the purpose of|just for|with respect to} {another|an additional|one more|yet another|a different|a further|one other|some other|an alternative|a second|one additional} patient {would be|could be|will be|can be|could well be|might be|is|might possibly be|may be|is going to be|could possibly be} {a|the|any|a new|some sort of|your|a good|an important|a fabulous|some|a real} short-term {experience|encounter|expertise|knowledge|practical experience|practical knowledge|working experience|go through|adventure|feel|past experiences} {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} discomfort {into a|right into a|in to a|in a|to a|right|towards a|perfectly into a|straight into a|suitable|proper} lifelong ordeal? {The|The actual|The particular|Your|This|A|Any|Typically the|All the|That|All of the} authors {of the|from the|with the|in the|on the|of your|within the|belonging to the|for the|of this|of one's} current {study|research|examine|review|analyze|analysis|investigation|go through|learn|exploration|understand}, {working|operating|functioning|doing work|performing|doing the job|working hard|being employed|earning a living|running|doing business} {under|below|beneath|underneath|less than|within|in|with|according to|lower than|using} {a|the|any|a new|some sort of|your|a good|an important|a fabulous|some|a real} federal {government|federal government|authorities|govt|federal|administration|governing administration|state|united states government|fed government|governing} initiative aimed {at|from|with|in|on|during|for|within|located at|by|found at} consolidating {research|study|investigation|analysis|exploration|homework|investigate|researching|groundwork|explore|examine} {on|upon|about|in|with|for|regarding|concerning|at|relating to|on the subject of} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains}, devised {a series of|a number of|some|a few|several|many|numerous|a range of|quite a few|a variety of} experiments {designed to|made to|built to|meant to|created to|intended to|which is designed to|manufactured to|developed to|which will|that will} {clarify|make clear|describe|explain|simplify|reveal|shed light on|clear up|demonstrate|illuminate|elucidate} {which|that|which usually|which in turn|which often|which will|in which|which unfortunately|that will|of which|which inturn} came {first|very first|initial|1st|initially|primary|to begin with|to start with|earliest|first of all|for starters}.{They|These people|They will|That they|Many people|People|Some people|These|Individuals|These products|They can} {did|do|would|does|performed|have|managed|made|could|had|have done} {so|therefore|thus|consequently|and so|hence|which means that|as a result|for that reason|which means|now} {by|through|simply by|by simply|by means of|by way of|by just|as a result of|from|just by|with} recruiting 46 subjects {who|that|which|whom|exactly who|who seem to|who actually|just who|what person|what individuals|who exactly} {had|experienced|acquired|got|received|obtained|possessed|have|previously had|found|enjoyed} {experienced|skilled|knowledgeable|seasoned|encountered|expert|professional|veteran|suffered|qualified|competent} {a|the|any|a new|some sort of|your|a good|an important|a fabulous|some|a real} {first|very first|initial|1st|initially|primary|to begin with|to start with|earliest|first of all|for starters} episode {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} {back|back again|again|rear|returning|backside|to come back|once again|spine|lower back|back once again} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} {had|experienced|acquired|got|received|obtained|possessed|have|previously had|found|enjoyed} {already|currently|previously|by now|presently|witout a doubt|undoubtedly|definitely|now|actually|without a doubt} lasted four {to|in order to|to be able to|for you to|to help|so that you can|that will|to help you|towards|to make sure you|to successfully} 16 weeks, {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} performing regular br #file_links<D>\keywords3.txt,{1|One|A single|One particular|Just one|A person|An individual|2|A|3|Only one},S] ain scans {on|upon|about|in|with|for|regarding|concerning|at|relating to|on the subject of} {those|individuals|these|people|all those|those people|the|the ones|some of those|many|persons} subjects {for a|for any|to get a|for the|for just a|for your|for that|to have a|for one|on a|to obtain a} {year|12 months|yr|calendar year|twelve months|season|year or so|365 days|time|month|couple of years}. Focusing {largely|mostly|mainly|generally|typically|primarily|basically|essentially|principally|predominantly|for the most part} {on the|around the|about the|for the|within the|to the|over the|in the|at the|relating to the|on your} bundles {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} axons {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} carry nerve {impulses|urges|desires|signals|current} acro #file_links<D>\keywords4.txt,{1|One|A single|One particular|Just one|A person|An individual|2|A|3|Only one},S] ss {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} brain, {they|these people|they will|that they|many people|people|some people|these|individuals|these products|they can} {found|discovered|identified|located|observed|uncovered|determined|noticed|seen|came across|encountered} {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} {within|inside|inside of|within just|in|throughout|in just|with|after only|around|during} {two|2|a couple of|a pair of|a couple|not one but two|only two|a few|several|couple of|pair of} {months|several weeks|weeks|a few months|many weeks|many months|several months|calendar months|a long time|times|days} {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} recruiting {patients|individuals|sufferers|people|clients|affected individuals|men and women|persons|subjects|folks|clientele}, discernible {differences|variations|distinctions|variances|dissimilarities|disparities|discrepancies|variation|issues|difficulties|variance} {in the|within the|inside the|from the|inside|while in the|during the|with the|on the|in your|through the} {structure|framework|construction|composition|design|shape|system|building|arrangement|plan|format} {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} integrity {of that|of this|of the|of these|of their|of your|of the particular|of a|of those|with the|of that particular} "white matter" {could be|might be|could possibly be|may be|may very well be|can be|may just be|is usually|will be|is often|could very well be} {used to|accustomed to|utilized to|employed to|familiar with|helpful to|useful to|would once|designed to|would always|which is used to} distinguish subjects whose {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} persisted {from|through|coming from|via|by|out of|with|as a result of|because of|right from|provided by} {those|individuals|these|people|all those|those people|the|the ones|some of those|many|persons} whose {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} {was|had been|has been|ended up being|seemed to be|appeared to be|was initially|was in fact|was basically|is|was indeed} {beginning|starting|commencing|start|starting point|starting up|outset|starting out|starting off|very beginning|newbie} {to|in order to|to be able to|for you to|to help|so that you can|that will|to help you|towards|to make sure you|to successfully} resolve.{By the|Through the|From the|With the|Because of the|By way of the|Via the|By|By your|Through|By way of} 12-month {mark|tag|indicate|level|draw|symbol|make|bench mark|label|signature|recognise}, {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} structural differen #file_links<D>\keywords2.txt,{1|One|A single|One particular|Just one|A person|An individual|2|A|3|Only one},S] ces {in|within|inside|throughout|with|around|during|on|when it comes to|for|found in} white matter allowed {researchers|scientists|experts|research workers|analysts|investigators|doctors|professionals|specialists|study workers|individuals} {to|in order to|to be able to|for you to|to help|so that you can|that will|to help you|towards|to make sure you|to successfully} distinguish -- {without|with out|without having|with no|devoid of|without the need of|not having|while not|free of|lacking|with no need of} error -- subjects whose {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} {had|experienced|acquired|got|received|obtained|possessed|have|previously had|found|enjoyed} disappeared {from|through|coming from|via|by|out of|with|as a result of|because of|right from|provided by} {those|individuals|these|people|all those|those people|the|the ones|some of those|many|persons} whose {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} {was|had been|has been|ended up being|seemed to be|appeared to be|was initially|was in fact|was basically|is|was indeed} persistent. {Compared to|When compared with|In comparison to|In comparison with|As compared to|When compared to|As compared with|Compared with|As opposed to|Versus|Compared to the} subjects whose {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} resolved, subjects whose {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} {would|might|would certainly|would likely|could|would probably|will|would most likely|would definitely|may|should} {become|turn out to be|grow to be|turn into|come to be|develop into|end up|turned out to be|grown to be|get|end up being} {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} {also|additionally|furthermore|in addition|likewise|as well|at the same time|moreover|even|equally|too} showed {differences|variations|distinctions|variances|dissimilarities|disparities|discrepancies|variation|issues|difficulties|variance} {in the|within the|inside the|from the|inside|while in the|during the|with the|on the|in your|through the} {density|denseness|thickness|occurrence|solidity|body|mass|occurance} {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} connections {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} lashed {their|their own|their particular|his or her|the|its|their very own|ones own|his / her|his or her's|your} nucleus accumbens -- {a|the|any|a new|some sort of|your|a good|an important|a fabulous|some|a real} {central|main|key|core|fundamental|middle|principal|essential|important|crucial|primary} {structure|framework|construction|composition|design|shape|system|building|arrangement|plan|format} {in the|within the|inside the|from the|inside|while in the|during the|with the|on the|in your|through the} brain rewards, {motivation|determination|inspiration|enthusiasm|drive|commitment|desire|willingness|incentive|reason|persistence}, pleasure {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} reinforcement learning {circuit|signal|routine|enterprise|world|outlet|rounds|program|regimen|track} -- together {with|along with|together with|using|having|by using|utilizing|through|with the help of|by means of|by way of} {their|their own|their particular|his or her|the|its|their very own|ones own|his / her|his or her's|your} medial prefrontal cortex, {a|the|any|a new|some sort of|your|a good|an important|a fabulous|some|a real} switchboard {for|with regard to|regarding|pertaining to|intended for|to get|designed for|meant for|for the purpose of|just for|with respect to} decision-making, emotional response {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} long-term {memory|storage|memory space|recollection|ram|reminiscence|remembrance|random access memory|mind|recall|storage area}.{The|The actual|The particular|Your|This|A|Any|Typically the|All the|That|All of the} authors {made|created|produced|manufactured|built|designed|crafted|constructed|developed|generated|prepared} {further|additional|more|even more|additionally|further more|even further|deeper|extra|farther|more deeply} comparisons {between|in between|among|involving|amongst|concerning|somewhere between|around|relating to|approximately|regarding} {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} {original|unique|authentic|initial|first|primary|genuine|classic|main|principal|traditional} 46 subjects {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} {two|2|a couple of|a pair of|a couple|not one but two|only two|a few|several|couple of|pair of} {new|brand new|fresh|brand-new|completely new|innovative|different|unique|latest|cutting edge|newer} {groups|teams|organizations|groupings|communities|categories|types|classes|sets|people|individuals}: {healthy|wholesome|healthful|balanced|nutritious|healthy and balanced|healthier|good|strong|nourishing|in good health} recruits {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} {people|individuals|folks|men and women|persons|people today|consumers|many people|most people|customers|families} {with a|having a|using a|which has a|that has a|by using a|which includes a|along with a|by having a|accompanied by a|having} established history {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains}. {Those|Individuals|These|People|All those|Those people|The|The ones|Some of those|Many|Persons} comparisons showed {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often}, {from the|in the|from your|through the|with the|on the|within the|belonging to the|out of the|of your|out of your} {earliest|very first|first|original|initial|most well-known|most ancient|initially|older|1st|oldest} scans, {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} brains {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} subjects {who|that|which|whom|exactly who|who seem to|who actually|just who|what person|what individuals|who exactly} {would|might|would certainly|would likely|could|would probably|will|would most likely|would definitely|may|should} go {on|upon|about|in|with|for|regarding|concerning|at|relating to|on the subject of} {to become|being|to get|for being|to be|to turn into|in becoming|to generally be|to start to be|that they are|to work as} {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} sufferers {had|experienced|acquired|got|received|obtained|possessed|have|previously had|found|enjoyed} structural abnormalities {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} {made|created|produced|manufactured|built|designed|crafted|constructed|developed|generated|prepared} {them|all of them|these|these people|these individuals|these folks|them all|him or her|these products|individuals|it} {look|appear|seem|search|glimpse|appearance|glance|start looking|take a look|look and feel|check} {much more|a lot more|far more|considerably more|additional|a great deal more|extra|way more|even more|a whole lot more|significantly more} {like the|such as the|just like the|much like the|including the|such as|similar to the|for example the|for instance the|which include the|enjoy the} {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} veterans {than|compared to|as compared to|when compared with|in comparison with|as compared with|compared with|as opposed to|rather than|when compared to|versus} {like|such as|just like|similar to|including|for instance|for example|enjoy|prefer|want|much like} {healthy|wholesome|healthful|balanced|nutritious|healthy and balanced|healthier|good|strong|nourishing|in good health} controls {or the|or even the|or perhaps the|or|and the|or maybe the|as well as|or even|or use the|as well as the|also know as the} subjects {with|along with|together with|using|having|by using|utilizing|through|with the help of|by means of|by way of} {back|back again|again|rear|returning|backside|to come back|once again|spine|lower back|back once again} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} went {away|aside|absent|apart|out|at a distance|away from|out there|gone|out and about|at bay}.{And|As well as|And also|Along with|In addition to|Plus|Together with|And even|Not to mention|And additionally|And then} {through|via|by means of|by way of|as a result of|by|thru|because of|by using|throughout|with} #file_links<D>\keywords1.txt,{1|One|A single|One particular|Just one|A person|An individual|2|A|3|Only one},S] out {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} {study|research|examine|review|analyze|analysis|investigation|go through|learn|exploration|understand} {period|time period|period of time|interval|time|phase|timeframe|moment|span|occasion|time frame}, {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} white matter {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} brain connections {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} subjects {with|along with|together with|using|having|by using|utilizing|through|with the help of|by means of|by way of} {back|back again|again|rear|returning|backside|to come back|once again|spine|lower back|back once again} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} went {away|aside|absent|apart|out|at a distance|away from|out there|gone|out and about|at bay} looked {much more|a lot more|far more|considerably more|additional|a great deal more|extra|way more|even more|a whole lot more|significantly more} {like|such as|just like|similar to|including|for instance|for example|enjoy|prefer|want|much like} {those|individuals|these|people|all those|those people|the|the ones|some of those|many|persons} {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} {healthy|wholesome|healthful|balanced|nutritious|healthy and balanced|healthier|good|strong|nourishing|in good health} {control|manage|handle|management|command|regulate|deal with|influence|restrain|manipulate|power} subjects {than|compared to|as compared to|when compared with|in comparison with|as compared with|compared with|as opposed to|rather than|when compared to|versus} {they|these people|they will|that they|many people|people|some people|these|individuals|these products|they can} {did|do|would|does|performed|have|managed|made|could|had|have done} {like the|such as the|just like the|much like the|including the|such as|similar to the|for example the|for instance the|which include the|enjoy the} brains {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} subjects whose {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} became {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged}.{The|The actual|The particular|Your|This|A|Any|Typically the|All the|That|All of the} brain's white matter {normally|usually|typically|generally|commonly|ordinarily|in most cases|regularly|routinely|often|in general} deteriorate {with|along with|together with|using|having|by using|utilizing|through|with the help of|by means of|by way of} age, {and the|and also the|as well as the|along with the|plus the|as well as|additionally, the|and also|and then the|together with the|also, the} Northwestern {researchers|scientists|experts|research workers|analysts|investigators|doctors|professionals|specialists|study workers|individuals} {made a|designed a|developed a|created a|produced|created|produced a|launched a|crafted a|developed|designed} shocking {calculation|computation|calculations|formula|working out} {to|in order to|to be able to|for you to|to help|so that you can|that will|to help you|towards|to make sure you|to successfully} {show|display|present|demonstrate|indicate|exhibit|clearly show|reveal|demonstrate to|express|illustrate} {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} {difference|distinction|variation|big difference|change|variance|main difference|significant difference|improvement|impact|major difference} {that|which|in which|that will|of which|this|which will|the fact that|which usually|who|which often} separated subjects {with|along with|together with|using|having|by using|utilizing|through|with the help of|by means of|by way of} {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} {without|with out|without having|with no|devoid of|without the need of|not having|while not|free of|lacking|with no need of} {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains}: {Compared to|When compared with|In comparison to|In comparison with|As compared to|When compared to|As compared with|Compared with|As opposed to|Versus|Compared to the} {healthy|wholesome|healthful|balanced|nutritious|healthy and balanced|healthier|good|strong|nourishing|in good health} controls {or|or even|or perhaps|as well as|or maybe|and also|or simply|or possibly|and / or|and|and even} {those|individuals|these|people|all those|those people|the|the ones|some of those|many|persons} whose {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} subsided, {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} white matter {in the|within the|inside the|from the|inside|while in the|during the|with the|on the|in your|through the} subjects whose {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains} {went on|continued|proceeded|took|started|made|began|left on|followed|happened|ongoing} {to become|being|to get|for being|to be|to turn into|in becoming|to generally be|to start to be|that they are|to work as} {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} "exhibits 30 {to|in order to|to be able to|for you to|to help|so that you can|that will|to help you|towards|to make sure you|to successfully} 50 {years|many years|a long time|decades|several years|ages|yrs|quite a few years|numerous years|years and years|many} {of|associated with|regarding|involving|connected with|with|for|from|in|about|involved with} {additional|extra|further|added|more|supplemental|even more|some other|various other|other|increased} aging."If {this|this particular|this kind of|this specific|that|the following|this unique|it|the|this approach|this valuable} {research|study|investigation|analysis|exploration|homework|investigate|researching|groundwork|explore|examine} holds {up|upward|upwards|way up|right up|in place|away|all the way up|together|" up "|further up}, {future|long term|potential|upcoming|foreseeable future|long run|potential future|near future|long term future|forthcoming|possible future} {patients|individuals|sufferers|people|clients|affected individuals|men and women|persons|subjects|folks|clientele} #file_links<D>\keywords5.txt,{1|One|A single|One particular|Just one|A person|An individual|2|A|3|Only one},S] may {want to|wish to|desire to|need to|would like to|choose to|prefer to|like to|plan to|just want to|have to} {know|understand|realize|recognize|learn|find out|fully understand|comprehend|discover|be aware of|are aware of} {what the|exactly what the|what are the|just what the|precisely what the|the|just what|how much the|the style the|specifically what the|what is the} stakes {are|tend to be|are usually|are generally|usually are|will be|happen to be|are actually|can be|really are|seem to be} {if|in the event that|when|in case|if perhaps|in the event|whenever|in cases where|should|any time|however, if} {they|these people|they will|that they|many people|people|some people|these|individuals|these products|they can} {get|obtain|acquire|find|receive|have|get hold of|secure|become|pick up|end up getting} {hurt|harm|damage|injure|injured|harmed|wounded|damaged|pain|distress|cause harm to}, {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} {make|help to make|help make|create|produce|generate|try to make|come up with|get|earn|cause} {their|their own|their particular|his or her|the|its|their very own|ones own|his / her|his or her's|your} recreational {and|as well as|and also|along with|in addition to|plus|together with|and even|not to mention|and additionally|and then} {career|profession|job|occupation|vocation|employment|work|professional|livelihood|position|line of work} {choices|options|alternatives|selections|possibilities|decisions|solutions|opportunities|picks|products|possible choices} accordingly. {So|Therefore|Thus|Consequently|And so|Hence|Which means that|As a result|For that reason|Which means|Now}, {too|as well|also|way too|far too|very|much too|at the same time|overly|likewise|extremely}, {might|may|may well|may possibly|could|could possibly|may perhaps|might possibly|can|will probably|may very well} {their|their own|their particular|his or her|the|its|their very own|ones own|his / her|his or her's|your} prospective employers -- {including|such as|which includes|which include|like|as well as|together with|this includes|for example|among them|incorporating} {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} armed forces, {the|the actual|the particular|your|this|a|any|typically the|all the|that|all of the} National Football League, {or a|or perhaps a|or even a|or possibly a|or maybe a|or simply a|or perhaps|as well as a|or just a|maybe a|or even} trucking {company|organization|business|firm|corporation|enterprise|provider|small business|business enterprise|supplier|service} {tired of|fed up with|sick and tired of|sick and tired with|tired with|fed up of|sick of|bored with|exhausted by|weary of|frustrated by} paying disability {to|in order to|to be able to|for you to|to help|so that you can|that will|to help you|towards|to make sure you|to successfully} drivers retiring {with|along with|together with|using|having|by using|utilizing|through|with the help of|by means of|by way of} {chronic|persistent|long-term|continual|serious|constant|severe|recurring|debilitating|reoccuring|prolonged} {back|back again|again|rear|returning|backside|to come back|once again|spine|lower back|back once again} {pain|discomfort|soreness|ache|agony|suffering|problems|anguish|serious pain|painfulness|pains}.