Splicing regulatory element

Splicing regulatory element (SRE) are trans-acting sequences in pre-mRNA, which either enhance or silence (suppress) the splicing of introns, or in general regulates the constitutive or alternative splicing. The "context dependence" of SREs is categorized into at least two studied groups: (a) the location-dependent activity of SREs: the activity varies with the relative positions of SREs in pre-mRNA; (b) the gene-dependent activity of SREs: the SRE activity observed in one gene is lost when the SRE is moved to another gene.^[1]

SREs are:

present in exons: exonic splicing enhancers (ESEs), exonic splicing silencers (ESSs)

present in introns: intronic splicing enhancers (ISEs), intronic splicing silencers (ISSs).

References

^ Wang, Zefeng (2008-05). "Splicing regulation: From a parts list of regulatory elements to an integrated splicing code". RNA. 14 (5): 802–813. doi:10.1261/rna.876308. ISSN 1355-8382. Retrieved 2013-08-15. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)

[1] Wang, Zefeng (2008-05). "Splicing regulation: From a parts list of regulatory elements to an integrated splicing code". RNA. 14 (5): 802–813. doi:10.1261/rna.876308. ISSN 1355-8382. Retrieved 2013-08-15. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)

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