C-terminal processing peptidase
| C-terminal processing peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.102 | ||||||||
| CAS no. | 92480-11-0&title= 216484-75-2, 92480-11-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
C-terminal processing peptidase (EC 3.4.21.102, CtpA gene product (Synechocystis sp.), photosystem II D1 protein processing peptidase, protease Re, tail-specific protease, Tsp protease) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala!Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. In the plant chloroplast, the enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II
Proteolytic processing of the D1 protein of photosystem II anables light-driven assembly of the tetranuclear manganese cluster.
References
- ^ Keiler, K.C. and Sauer, R.T. (1998). "Tsp protease". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (ed.). Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 460–461.
{{cite book}}: CS1 maint: multiple names: authors list (link) - ^ Beebe, K.D., Shin, J.N., Peng, J., Chaudhury, C., Khera, J. and Pei, D.H. (2000). "Substrate recognition through a PDZ domain in tail-specific protease". Biochemistry. 39: 3149–3155. PMID 10715137.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Liao, D.I., Qian, J., Chisholm, D.A., Jordan, D.B. and Diner, B.A. (2000). "Crystal structures of the photosystem II D1 C-terminal processing protease". Nat. Struct. Biol. 7: 749–753. PMID 10966643.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- C-terminal+processing+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)