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Multisystem developmental disorder

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Multisystem developmental disorder (MSDD) is a term used by Stanley Greenspan to describe children under age 3 who exhibit signs of impaired communication as in autism, but with strong emotional attachments atypical of autism.[citation needed] It is described in the DC:0-3R manual.[1]

Other uses of the term

The term multisystem developmental disorder has also been used to describe various developmental disorders. These include:

  • Cornelia de Lange syndrome,[2] an autosomal dominant disorder characterized by short stature, excessive hairiness, mental retardation, and problems with the sensory organs such as hearing loss, dry eyes, and lack of sensitivity to pain.[3]
  • Alagille syndrome,[4] an autosomal dominant disorder with a wide range of features and manifestations. Its five most significant features are chronic choleostasis, a condition where bile cannot flow from the liver to the duodenum, occurring in 95% of cases; heart abnormalities (over 90%); butterfly vertebrae; posterior embryotoxon and a distinctive face (prominent forehead, deep-set eyes, and a pointed chin).[5]
  • Rubinstein-Taybi syndrome[6], a mental retardation syndrome characterized by broad thumbs, facial abnormalities, and big toes alongside mental retardation.[7]
  • Renal-coloboma syndrome[8]
  • Williams syndrome,[9][10] a neurodevelopmental disorder characterized by a unique profile of strengths and deficits; most with the condition have mild mental retardation but have grammatical and lexical abilities above what would be expected from their IQs.[11] They are hypersocial and empathetic, but social isolation is commonly experienced.[12]
  • Proteus syndrome,[13] a congenital disorder causing disproportionate growth of skin, bone, and other tissues.[14]
  • Asphyxiating thoracic dysplasia,[15] a autosomal recessive skeletal disorder with an estimated prevalence of between 1 in 100,000 and 1 in 130,000 live births.[16]

Symptoms

  • Toe walking[17]
  • Pragmatic speech problems[18]
  • Clumsiness[19]
  • Obsessions and rituals[20]
  • Sensory issues[21]
  • Disinterest in social interaction[22]
  • Autistic characteristics[23]

References

  1. ^ . doi:10.1037/a0021026. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  2. ^ . doi:10.1186/1757-1626-1-329. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)CS1 maint: unflagged free DOI (link)
  3. ^ Woliver, Robbie. Alphabet Kids. pp. 160, 161.
  4. ^ . doi:10.1002/ajmg.10608. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  5. ^ . doi:10.1038/ejhg.2011.181. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  6. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 8726717, please use {{cite journal}} with |pmid=8726717 instead.
  7. ^ . PMID 3629765. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  8. ^ . doi:10.1034/j.1399-0004.1999.560101.x. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  9. ^ . doi:10.1111/j.1399-0004.1998.tb03715.x. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  10. ^ . doi:10.1007/s00508-006-0658-2. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  11. ^ Bellugi, Ursula; Wang, Paul P.; Jernigan, Terry L. (1994). "Williams syndrome: An unusual neuropsychological profile". In Broman, Sarah H.; Grafman, Jordan (eds.). Atypical cognitive deficits in developmental disorders: Implications for brain function. pp. 23–56. ISBN 978-0-8058-1180-3.
  12. ^ Williams-Beuren Syndrome: Research, Evaluation, and Treatment. p. 237.
  13. ^ . PMID 22514103. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  14. ^ . doi:10.1007/s11832-011-0350-6. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  15. ^ . doi:10.1136/jmg.40.6.431. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  16. ^ Tongsong, Theera; Chanprapaph, Pharuhus; Thongpadungroj, Tidarat. PMID 10447085 http://www.jultrasoundmed.org/cgi/pmidlookup?view=long&pmid=10447085. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  17. ^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
  18. ^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
  19. ^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
  20. ^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
  21. ^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
  22. ^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
  23. ^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.

Sources

PubMed

  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11579660, please use {{cite journal}} with |pmid=11579660 instead.

Other sources