Multisystem developmental disorder

Multisystem developmental disorder (MSDD) is a term used by Stanley Greenspan to describe children under age 3 who exhibit signs of impaired communication as in autism, but with strong emotional attachments atypical of autism.^{[citation needed]} It is described in the DC:0-3R manual.^[1]

Other uses of the term

The term multisystem developmental disorder has also been used to describe various developmental disorders. These include:

Cornelia de Lange syndrome^[2], an autosomal-dominant disorder characterized by short stature, excessive hairiness, mental retardation, and problems with the sensory organs such as hearing loss, dry eyes, and lack of sensitivity to pain.^[3]
Alagille syndrome^[4], an autosomal-dominant disorder with a wide range of features and manifestations. Its five most significant features are chronic choleostasis, a condition where bile cannot flow from the liver to the duodenum, occurring in 95% of cases; heart abnormalities (over 90%); butterfly vertebrae; posterior embryotoxon and a distinctive face (prominent forehead, deep-set eyes, and a pointed chin)^[5].
Rubinstein-Taybi syndrome^[6]
Renal-coloboma syndrome^[7]
Williams syndrome.^[8]^[9]
Proteus syndrome^[10]
Asphyxiating thoracic dysplasia^[11]

Symptoms

Toe walking^[12]
Pragmatic speech problems^[13]
Clumsiness^[14]
Obsessions and rituals^[15]
Sensory issues^[16]
Disinterest in social interaction^[17]
Autistic characteristics^[18]

References

^ "Developmentally-Sensitive Diagnostic Criteria for Mental Health Disorders in Early Childhood: DSM-IV, RDC-PA, and the revised DC: 0-3". 2011. {{cite journal}}: Cite journal requires |journal= (help); Unknown parameter |month= ignored (help)
^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19019222, please use {{cite journal}} with |pmid=19019222 instead.
^ Woliver, Robbie. Alphabet Kids. pp. 160, 161.
^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 12244552, please use {{cite journal}} with |pmid=12244552 instead.
^ Turnpenny, Peter (2011). "Alagille syndrome: pathogenesis, diagnosis and management". European Journal of Human Genetics. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 8726717, please use {{cite journal}} with |pmid=8726717 instead.
^ "Renal-coloboma syndrome: a multi-system developmental disorder caused by PAX2 mutations". Clinical Genetics. 56. 1999. {{cite journal}}: Unknown parameter |month= ignored (help)
^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 9761391, please use {{cite journal}} with |pmid=9761391 instead.
^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17009066, please use {{cite journal}} with |pmid=17009066 instead.
^ "Imaging manifestations in Proteus syndrome: an unusual multisystem developmental disorder". 18. {{cite journal}}: Check date values in: |date= and |year= / |date= mismatch (help); Cite journal requires |journal= (help); Unknown parameter |month= ignored (help)
^ "A locus for asphyxiating thoracic dystrophy, ATD, maps to chromosome 15q13". 40 (6). 2003. Retrieved 24/04/2013. {{cite journal}}: Check date values in: |accessdate= (help); Cite journal requires |journal= (help); Unknown parameter |month= ignored (help)
^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.
^ Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.

Sources

PubMed

Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11579660, please use {{cite journal}} with |pmid=11579660 instead.

Other sources

Multisystem Developmental Disorder, Developmental Behavior Pediatrics Online
Increasing Interaction with Children with Multisystem Developmental Disorder (MSDD), Developmental Delay Resources
Integrated Treatment Approaches for Young Children with Multisystem Developmental Disorder, Education Resources Information Center

This autism-related article is a stub. You can help Wikipedia by expanding it.

[1] "Developmentally-Sensitive Diagnostic Criteria for Mental Health Disorders in Early Childhood: DSM-IV, RDC-PA, and the revised DC: 0-3". 2011. {{cite journal}}: Cite journal requires |journal= (help); Unknown parameter |month= ignored (help)

[cdl-2] Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19019222, please use {{cite journal}} with |pmid=19019222 instead.

[3] Woliver, Robbie. Alphabet Kids. pp. 160, 161.

[a-4] Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 12244552, please use {{cite journal}} with |pmid=12244552 instead.

[5] Turnpenny, Peter (2011). "Alagille syndrome: pathogenesis, diagnosis and management". European Journal of Human Genetics. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

[rt-6] Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 8726717, please use {{cite journal}} with |pmid=8726717 instead.

[7] "Renal-coloboma syndrome: a multi-system developmental disorder caused by PAX2 mutations". Clinical Genetics. 56. 1999. {{cite journal}}: Unknown parameter |month= ignored (help)

[w-8] Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 9761391, please use {{cite journal}} with |pmid=9761391 instead.

[wb-9] Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17009066, please use {{cite journal}} with |pmid=17009066 instead.

[10] "Imaging manifestations in Proteus syndrome: an unusual multisystem developmental disorder". 18. {{cite journal}}: Check date values in: |date= and |year= / |date= mismatch (help); Cite journal requires |journal= (help); Unknown parameter |month= ignored (help)

[11] "A locus for asphyxiating thoracic dystrophy, ATD, maps to chromosome 15q13". 40 (6). 2003. Retrieved 24/04/2013. {{cite journal}}: Check date values in: |accessdate= (help); Cite journal requires |journal= (help); Unknown parameter |month= ignored (help)

[12] Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.

[13] Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.

[14] Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.

[15] Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.

[16] Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.

[17] Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.

[18] Woliver, Robbie (2009). Alphabet Kids. Jessica Kingsley Publishers. p. 295.

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v t e Autism
Main	Causes Diagnosis Epidemiology Epigenetics Heritability History Memory Pathophysiology Sex and gender Societal and cultural aspects Therapies
Diagnoses	Pervasive developmental disorder Autistic disorder Asperger syndrome Pervasive developmental disorder not otherwise specified Childhood disintegrative disorder High-functioning autism
Associated conditions and phenomena	Alexithymia Anxiety LGBTQ identities Burnout Catatonia Masking Meltdowns Inertia Echolalia Echopraxia Emotional dysregulation Hyperlexia Infodumping Late talker Monotropism Nonspeaking Pathological demand avoidance Pronoun reversal Savant syndrome Special interests Stimming Sensory overload
Comorbid conditions	Attention deficit hyperactivity disorder Avoidant/restrictive food intake disorder Avoidant personality disorder Anxiety disorder obsessive–compulsive disorder Bipolar disorder Developmental coordination disorder Developmental verbal dyspraxia Epilepsy Gender dysphoria Global developmental delay Intellectual disability Major depressive disorder Schizoid personality disorder Sensory processing disorder Sleep disorder Suicide Tinnitus
Associated syndromes	22q13 deletion syndrome Angelman syndrome CHARGE syndrome Cohen syndrome Cornelia de Lange syndrome DiGeorge syndrome Down syndrome Fetal valproate spectrum disorder Fragile X syndrome MECP2 duplication syndrome Neurofibromatosis type I Noonan syndrome Multiple hamartoma syndrome Rett syndrome Smith–Lemli–Opitz syndrome Timothy syndrome Tuberous sclerosis Williams syndrome
Related issues	Ableism Autistic rights movement Critical autism studies Discrimination Double empathy problem Employment Multiple complex developmental disorder Neurodiversity Neuroqueer theory Peripheral neuropathy Reduced affect display Sanism Self-harm Suicidal ideation TEACCH program Twice exceptional Violence and autism
Controversies	Facilitated communication Lancet MMR autism fraud MMR vaccine Rapid prompting method Thiomersal Chelation Combating Autism Act Autistic supremacism
Diagnostic scales	Autism Diagnostic Interview Autism Diagnostic Observation Schedule Childhood Autism Rating Scale Gilliam Asperger's disorder scale
Screening scales	Autism-spectrum quotient Childhood Autism Spectrum Test Ritvo Autism and Asperger Diagnostic Scale
Lists	Autism-related topics Fictional characters Schools
Accommodations	Autism-friendly Curb cut effect Inclusive design Neurodiversity and labor rights Neuroinclusive design Sensory friendly Supported employment Universal design
Category