Screened Coulomb potentials implicit solvent model

SCP-ISM stands for Screened Coulomb Potentials Implicit Solvent Model. It is used to simulate solvent effects on macromolecules of biological relevance, such as proteins and nucleic acids. It is based on the classic theory of polar liquids, as developed by Debye and corrected by Onsager to incorporate reaction field effects. The model can be combined with quantum chemical calculations to formally derive a continuum model of solvent effects suitable for computer simulations of small and large molecular systems. See CHARMM (www.charmm.org) and documentation therein.