Signal transducing adaptor protein

Signal transducing adaptor proteins are proteins which are accessory to main proteins in a signal transduction pathway. These proteins tend to lack any intrinsic enzymatic activity themselves but instead mediate specific protein–protein interactions that drive the formation of protein complexes. Examples of adaptor proteins include MyD88, Grb2 and SHC1.

Signalling components

Much of the specificity of signal transduction depends on the recruitment of several signalling components such as protein kinases and G-protein GTPases into short lived active complexes in response to an activating signal such as a growth factor binding to its receptor.

Domains

Adaptor proteins usually contain several domains within their structure (e.g., Src homology 2 (SH2) and SH3 domains) which allow specific interactions with several other specific proteins. SH2 domains recognise specific amino acid sequences within proteins containing phosphotyrosine residues and SH3 domains recognise proline-rich sequences within specific peptide sequence contexts of proteins.

There are many other types of interaction domains found within adaptor and other signalling proteins which allow a rich diversity of specific and coordinated protein–protein interactions to occur within the cell during signal transduction.

Genes

Genes encoding adaptor proteins include:

• BCAR3 – Breast cancer anti-estrogen resistance protein 3
• GRAP – GRB2-related adaptor protein
• GRAP2 – GRB2-related adaptor protein 2
• LDLRAP1 – low density lipoprotein receptor adaptor protein 1
• NCK1 – NCK adaptor protein 1
• NCK2 – NCK adaptor protein 2
• NOS1AP – nitric oxide synthase 1 (neuronal) adaptor protein
• PIK3AP1 – phosphoinositide-3-kinase adaptor protein 1
• SH2B1 – SH2B adaptor protein 1
• SH2B2 – SH2B adaptor protein 2
• SH2B3 – SH2B adaptor protein 3
• SH2D3A -SH2 domain containing 3A
• SH2D3C – SH2 domain containing 3C
• SHB – Src homology 2 domain containing adaptor protein B
• SLC4A1AP – solute carrier family 4 (anion exchanger), member 1, adaptor protein
• GAB2 – GRB2-associated binding protein 2

See also

• Wikipedia:MeSH_D12.776#MeSH_D12.776.157.057_---_adaptor_proteins.2C_signal_transducing
• Wikipedia:MeSH_D12.776#MeSH_D12.776.543.990.150_---_adaptor_proteins.2C_vesicular_transport

Further Reading

• TAB2 is an adaptor protein involved in the IL-1 signal transduction pathway: Takaesu, Giichi; Kishida, Satoshi; Hiyama, Atsushi; Yamaguchi, Kyoko; Shibuya, Hiroshi; Irie, Kenji; Ninomiya-Tsuji, Jun; Matsumoto, Kunihiro (2000). "TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway". Molecular Cell. 5 (4): 649–658. doi:10.1016/S1097-2765(00)80244-0. ISSN 1097-2765.
• Good article about adaptor proteins involved in protein kinase C-mediated signal transduction: Schechtman D, Mochly-Rosen D (2001). "Adaptor proteins in protein kinase C-mediated signal transduction". Oncogene. 20 (44): 6339–47. doi:10.1038/sj.onc.1204778. PMID 11607837. Retrieved 2012-09-05. {{cite journal}}: Unknown parameter |month= ignored (help)
• A good article regarding the role of adaptor proteins involved with the T-cell antigen receptor: Samelson, Lawrence E. (2002). "SIGNALTRANSDUCTIONMEDIATED BY THET CELLANTIGENRECEPTOR: The Role of Adapter Proteins*". Annual Review of Immunology. 20 (1): 371–394. doi:10.1146/annurev.immunol.20.092601.111357. ISSN 0732-0582.