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Pyruvate oxidation

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Pyruvate Oxidation

Pyruvate Oxidation is the step which connects glycolysis to Krebs Cycle. It takes the two pryuvate molecules from glycolysis and transports them from the cytoplasm, through the two mitochondrial membranes into the matrix. Once inside a multienzyme complex catalyzes three changes:

1. a CO2 portion of the pyruvate is removed.
2. a NAD+ is reduced by two hydrogen atoms (which are obtained from food)
3. Coenzyme A is attached to the acetic acid portion (acetyl group)

The newly formed acetyl-CoA now moves on too Krebs Cycle.

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