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Microprocessor complex subunit DGCR8

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Pasha, also known as DGCR8 in vertebrates organisms, is a protein localized to the cell nucleus that is required for microRNA processing. It binds to Drosha, an RNase III enzyme, to form the Microprocessor complex that cleaves a primary transcript known as pri-miRNA to a characteristic stem-loop structure known as a pre-miRNA, which is then further processed to miRNA fragments by the enzyme Dicer. Pasha contains an RNA-binding domain and is thought to bind pri-miRNA to stabilize it for processing by Drosha.

References

  • Yeom, KH; Lee, Y; Han, J; Suh, MR; Kim, VN (2006). "Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing". Nucleic acids research. 34 (16): 4622–9. doi:10.1093/nar/gkl458. PMC 1636349. PMID 16963499.
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