Structure validation
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Macromolecular structure validation is primarily concerned with the methods developed and used to understand and ensure the quality of 3D models depicting macromolecular structures.
The need for this arises because different groups use macromolecular structure models for different purposes and these uses require a thorough understanding of the validity of the structure models. The various areas where structure validation may be important include: - R&D professionals - Journal editors and referees - Experimentalists using determined structures to provide insights for their work - Educators - Clinicians - Intellectual property experts?
There are three primary macromolecular structure determination methodologies which validation methods are typically applied to. They are: X-ray crystallography (X-ray) Nuclear Magnetic Resonance Spectroscopy (NMR) Cryo-electron microscopy (CryoEM)