lin-4 microRNA precursor
| lin-4 microRNA precursor | |
|---|---|
 Predicted secondary structure and sequence conservation of lin-4 | |
| Identifiers | |
| Symbol | lin-4 |
| Rfam | RF00052 |
| miRBase | MI0000002 |
| miRBase family | MIPF0000303 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
lin-4 is a microRNA (miRNA) that was identified from a study of developmental timing in C. elegans [1][2]. It was the first to be discovered of the miRNAs, a class of non-coding RNAs involved in gene regulation [3]. lin-4 is found on chromosome II in C. elegans and is complementary to sequences in the 3' untranslated region (UTR) of lin-14 mRNA. lin-4 acts to developmentally repress the accumulation of LIN-14 protein[4]. lin-4 also targets lin-28 and reduces protein expression[5]. miRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The products are thought to have regulatory roles through complementarity to mRNA.
References
- ^ Lee RC, Feinbaum RL, Ambros V (1993). "The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14". Cell. 75 (5): 843–854. doi:10.1016/0092-8674(93)90529-Y. PMID 8252621.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Rougvie, AE (2001). "Control of developmental timing in animals". Nat Rev Genet. 2 (9): 690–701. doi:10.1038/35088566. PMID 11533718.
- ^ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ Olsen PH, Ambros V (1999). "The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation". Dev. Biol. 216 (2): 671–80. doi:10.1006/dbio.1999.9523. PMID 10642801.
- ^ Bagga S, Bracht J, Hunter S; et al. (2005). "Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation". Cell. 122 (4): 553–63. doi:10.1016/j.cell.2005.07.031. PMID 16122423.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
External links
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