Pyruvate dehydrogenase (NADP+)
| Pyruvate dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.1.51 | ||||||||
| CAS no. | 93389-35-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Pyruvate dehydrogenase (NADP+) EC 1.2.1.51 is an enzyme that should not be confused with Pyruvate dehydrogenase (acetyltransferase) EC 1.2.4.1.[1][2]
It catalyzes the following reaction:
- Pyruvate + Coenzyme A + NADP+ ⇒ acetyl-CoA + NADPH + H+ + CO2
References
Bibliography
- "Localization of pyruvate: NADP+ oxidoreductase in sporozoites of Cryptosporidium parvum". J. Eukaryot. Microbiol. (Issue 53): 225–231. 2006.
{{cite journal}}:|issue=has extra text (help); Unknown parameter|authors=ignored (help) - "Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis". J. Biochem. (Issue 96): 931–934. 1984. PMID 6438078.
{{cite journal}}:|issue=has extra text (help); Unknown parameter|authors=ignored (help) - "The physiological role of oxygen-sensitive pyruvate dehydrogenase in mitochondrial fatty acid synthesis in Euglena gracilis". Arch. Biochem. Biophys. (Issue 237): 423–429. 1985.
{{cite journal}}:|issue=has extra text (help); Unknown parameter|authors=ignored (help) - "Pyruvate: NADP+ oxidoreductase from Euglena gracilis: the kinetic properties of the enzyme". Arch. Biochem. Biophys. (Issue 274): 434–442. 1989.
{{cite journal}}:|issue=has extra text (help); Unknown parameter|authors=ignored (help) - "Pyruvate: NADP+ oxidoreductase from Euglena gracilis: mechanism of O2-inactivation of the enzyme and its stability in the aerobe". Arch. Biochem. Biophys. (Issue 280): 292–298. 1990).
{{cite journal}}:|issue=has extra text (help); Check date values in:|year=(help); Unknown parameter|authors=ignored (help)CS1 maint: year (link) - "Purification and characterization of pyruvate: NADP+ oxidoreductase in Euglena gracilis". J. Biol. Chem. (Issue 262): 9130–9135. 1987. PMID 3110154.
{{cite journal}}:|issue=has extra text (help); Unknown parameter|authors=ignored (help) - "Pyruvate: NADP+ oxidoreductase from Euglena gracilis: limited proteolysis of the enzyme with trypsin". Arch. Biochem. Biophys (Issue 286): 270–276. 1991.
{{cite journal}}:|issue=has extra text (help); Unknown parameter|authors=ignored (help) - "NADP+-specific 2-oxoglutarate dehydrogenase in denitrifying Pseudomonas species". Arch. Microbiol. (Issue 153): 226–229. 1990.
{{cite journal}}:|issue=has extra text (help); Unknown parameter|authors=ignored (help) - "The origin of pyruvate: NADP oxidoreductase in mitochondria of Euglena gracilis". FEBS Lett. (Issue 479): 155–156. 2000.
{{cite journal}}:|issue=has extra text (help); Unknown parameter|authors=ignored (help) - "Pyruvate: NADP+ oxidoreductase is stabilized by its cofactor, thiamin pyrophosphate, in mitochondria of Euglena gracilis". Arch. Biochem. Biophys. (Issue 11): 183–188. 2003.
{{cite journal}}:|issue=has extra text (help); Unknown parameter|authors=ignored (help) - "Key role for transketolase activity in erythritol production by Trichosporonoides megachiliensis SN-G42". J. Biosci. Bioeng. (Issue Issue 108): 385–390. 2009.
{{cite journal}}:|issue=has extra text (help); Unknown parameter|authors=ignored (help)
External links
- EC 1.2.1.51 IUBMB Enzyme Nomenclature at chem.qmul.ac.uk
- EC 1.2.1.51 - pyruvate dehydrogenase (NADP+) at Brenda-enzymes.org
- ENZYME entry: EC 1.2.1.51 at Enzyme.expasy.org
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