Trans-regulatory element
Trans-regulatory elements are genes which may modify (or regulate) the expression of distant genes.[1] More specifically, trans-regulatory elements are DNA sequences that encode transcription factors.
Trans-regulatory elements work through an intermolecular interaction between two different molecules: (1) a transcribed and translated transcription factor protein derived from the trans-regulatory element and a (2) DNA regulatory element that is adjacent to the regulated gene. This is in contrast to cis-regulatory elements that work through an intramolecular interaction between different parts of the same molecule: (1) a gene and (2) an adjacent regulatory element for that gene in the same DNA molecule.
Properties of trans-acting factors include: [2]
1. subunits of RNA polymerase
2. bind to RNA polymerase to stabilize the initiation complex
3. bind to all promoters at specific sequences, but not to RNA polymerase (TFIID factors)
4. bind to a few promoters and are required for transcription initiation (positive regulators of gene expression)
See also
References
- ^ Gilad Y, Rifkin SA, Pritchard JK (2008). "Revealing the architecture of gene regulation: the promise of eQTL studies". Trends Genet. 24 (8): 408–15. doi:10.1016/j.tig.2008.06.001. PMC 2583071. PMID 18597885.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ McClean, Phillip. "Cis-Acting element adn trans-acting factors". 1998.
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