C-DNA

C-DNA also known as C form DNA. It is one of the many possible double helical structures of DNA. This form of DNA can be observed at some conditions such as relatively low humidity and the presence of certain ions, such as Li⁺ or Mg²⁺.

Recent research suggests that both C-DNA and B-DNA consist of two distinct nucleotide conformations, B-I and B-II. The ratio of B-II conformation in C-DNA is more than 40%. However, the ratio of B-II conformation in B-DNA is only about 10%.

See also

• B-DNA
• A-DNA
• Mechanical properties of DNA

C-DNA (complementary or clonal DNA ) is a type of DNA used to describe libraries of genetic information. C-DNA is used in testing for pharmaceuticals and research of diseases. C-DNA is a complementary strand that is transcribed in laboratories to create genes. Genetic engineering also uses these DNA libraries to create modified versions of genomic information. This form of DNA can be observed at some conditions such as relatively low humidity and the presence of certain ions such as Li+ or Mg2+

References

• L van Dam, M H Levitt (2000). "BII nucleotides in the B and C forms of natural-sequence polymeric DNA: A new model for the C form of DNA". J Mol Biol. 304 (4): 541–61. doi:10.1006/jmbi.2000.4194. PMID 11099379.