Duck HBV RNA encapsidation signal epsilon
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| Duck HBV RNA encapsidation signal epsilon | |
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| Other data | |
| PDB structures | PDBe |
The Duck HBV RNA encapsidation signal epsilon (DHBV_epsilon) is an RNA structure that is shown to facilitate encapsidation of the pregenomic RNA required for replication.
DHBV is used as a model to understand human HBV. DHBV epsilon consists of a stem structure, a bulge and an apical stem loop. The RNA structure was determined by chemical probing, NMR analysis and by mutagenesis.[1]
A recent NMR analysis of the DHBV epsilon have shown that the apical loop to be capped by a stable well-structured UGUU tetraloop.[2]
See also
References
- ^ Smith Gj, 3rd; Donello, JE; Lück, R; Steger, G; Hope, TJ (1998). "The hepatitis B virus post-transcriptional regulatory element contains two conserved RNA stem-loops which are required for function". Nucleic Acids Research. 26 (21): 4818–27. doi:10.1093/nar/26.21.4818. PMC 147918. PMID 9776740.
{{cite journal}}: CS1 maint: numeric names: authors list (link) - ^ Girard, FC; Ottink, OM; Ampt, KA; Tessari, M; Wijmenga, SS (2007). "Thermodynamics and NMR studies on Duck, Heron and Human HBV encapsidation signals". Nucleic Acids Research. 35 (8): 2800–11. doi:10.1093/nar/gkm131. PMC 1885660. PMID 17430968.
External links
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