Avian HBV RNA encapsidation signal epsilon
| Avian HBV RNA encapsidation signal epsilon | |
|---|---|
| Identifiers | |
| Other data | |
| PDB structures | PDBe |
The Heron HBV RNA encapsidation signal epsilon (HHBV_epsilon) is an RNA structure that is shown to facilitate encapsidation of the pregenomic RNA required for replication.
The HHBV epsilon consists of a stem structure, a bulge and an apical stem-loop. The RNA structure has been determined by chemical probing and by mutagenesis.[1]
A recent NMR analysis of the HHBV epsilon have shown that the apical loop to be capped by a stable well-structured UGUU tetraloop.[2]
See also
References
- ^ Beck, J; Nassal, M (1997). "Sequence- and structure-specific determinants in the interaction between the RNA encapsidation signal and reverse transcriptase of avian hepatitis B viruses". Journal of virology. 71 (7): 4971–80. PMC 191728. PMID 9188560.
- ^ Girard, FC; Ottink, OM; Ampt, KA; Tessari, M; Wijmenga, SS (2007). "Thermodynamics and NMR studies on Duck, Heron and Human HBV encapsidation signals". Nucleic acids research. 35 (8): 2800–11. doi:10.1093/nar/gkm131. PMC 1885660. PMID 17430968.
External links
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