Hydroxypethidine

Hydroxypethidine
Clinical data
ATC code	none;
Identifiers
	IUPAC name Ethyl 4-(3-hydroxyphenyl)-1-methyl-piperidine-4-carboxylate;
CAS Number	468-56-4;
PubChem CID	61120;
ChemSpider	55068 ;
UNII	W1J43H2B3K;
CompTox Dashboard (EPA)	DTXSID90196941 ;
ECHA InfoCard	100.006.738
Chemical and physical data
Formula	C15H21NO3
Molar mass	263.332 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)C2(c1cccc(O)c1)CCN(C)CC2;
	InChI InChI=1S/C15H21NO3/c1-3-19-14(18)15(7-9-16(2)10-8-15)12-5-4-6-13(17)11-12/h4-6,11,17H,3,7-10H2,1-2H3 ; Key:WTJBNMUWRKPFRS-UHFFFAOYSA-N ;
	(verify)

Hydroxypethidine (Bemidone) is an opioid analgesic that is an analogue of pethidine (meperidine). Hydroxypethidine is significantly less potent than meperidine as an analgesic, (0.3x meperidine in potency) although it also has NMDA antagonist properties like its close relative ketobemidone.^[1]

Hydroxypethidine has similar effects to other opioids, and produces analgesia, sedation and euphoria. Side effects can include itching, nausea and potentially serious respiratory depression which can be life-threatening.

References

^ Isbell Harris. The addiction liability of some analogues of meperidine. Journal of Pharmacology And Experimental Therapeutics, 1949; 97(2): 182-190

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[1] Isbell Harris. The addiction liability of some analogues of meperidine. Journal of Pharmacology And Experimental Therapeutics, 1949; 97(2): 182-190

[1]

See also

References