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HBV RNA encapsidation signal epsilon

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HBV RNA encapsidation signal epsilon
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Other data
PDB structuresPDBe

The HBV RNA encapsidation signal epsilon is an element essential for HBV virus replication.

It is an RNA structure situated near the 5' end of the HBV pregenomic RNA.[1] The structure consists of a lower stem, a bulge region, an upper stem and a tri-loop. The structure was determined and refined through enzymatic probing and NMR spectroscopy.[2] The closure of the tri-loop was not predicted by RNA structure prediction programs but observed in the NMR structure. The region shown to be critical for encapsidation of the RNA in the viral lifecycle are the bulge, upper stem and tri-loop which interact with the terminal protein domain of the HBV viral polymerase.[3]

See also

References

  1. ^ Beck J, Nassal M (2007). "Hepatitis B virus replication". World J. Gastroenterol. 13 (1): 48–64. PMID 17206754. {{cite journal}}: Unknown parameter |month= ignored (help)
  2. ^ Flodell S, Schleucher J, Cromsigt J, Ippel H, Kidd-Ljunggren K, Wijmenga S (2002). "The apical stem-loop of the hepatitis B virus encapsidation signal folds into a stable tri-loop with two underlying pyrimidine bulges". Nucleic Acids Res. 30 (21): 4803–4811. doi:10.1093/nar/gkf603. PMC 135823. PMID 12409471. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ Kramvis A, Kew MC (1998). "Structure and function of the encapsidation signal of hepadnaviridae". J. Viral Hepat. 5 (6): 357–367. doi:10.1046/j.1365-2893.1998.00124.x. PMID 9857345. {{cite journal}}: Unknown parameter |month= ignored (help)


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