Complement component 5
Template:PBB Complement component 5 is a protein involved in the complement system.
It is cleaved into C5a and C5b:
- C5a plays an important role in chemotaxis.[1]
- C5b forms the first part of the complement membrane attack complex.
Deficiency is thought to cause Leiner's disease.
The drug eculizumab prevents cleavage of C5 into C5a and C5b.[2]
References
- ^ Immunology at MCG 1/phagocyt
- ^ Dubois E, Cohen A (2009). "Eculizumab". Br J Clin Pharmacol. 68: 318–319. doi:10.1111/j.1365-2125.2009.03491.x. PMC 2766470.
Further reading
- Fredslund F, Laursen NS, Roversi P; et al. (2008). "Structure of and influence of a tick complement inhibitor on human complement component 5". Nat Immunol. 9 (7): 753–60. doi:10.1038/ni.1625. PMID 18536718.
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External links
- Complement+5 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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