ATC code
ATC code (Anatomic Therapeutical Chemical) is a drug classification system. In the ATC system drugs are divided into different groups and sub-groups, according on which part of the body the act, and also on the basis of their therapeutical, pharmaceutical and chemical properties. There are 5 levels in the ATC classification system. In the first level, the drugs are divided in 14 main groups. Each of these 14 groups is furthermore divided into 4 sub-groups. The second and the third subgroup are pharmaceutical or therapeutical sub-groups. The fourth sub-group indicates the chemical, therapeutical or pharmacological group the substance belongs to. The last sub-group is the individual substance
For example, ciprofloxacin's ATC code would be J01MA02
- J Anti-infectives for systemic use
- J01 Antibacterials for systemic use
- J01M Quinolone antibacterials
- J01MA Fluoroquinolones
- J01MA02 Ciprofloxacin
- J01MA Fluoroquinolones
- J01M Quinolone antibacterials
- J01 Antibacterials for systemic use
List of ATC groups
A Alimentary tract and metabolism
- A01 Stomatological preparations
- A01A Stomatological preparations
- A01AA Caries prophylactic agents
- A01AB Anti-infectives and antiseptics for local oral treatment
- A01AC Corticosteroids for local oral treatment
- A01AD Other agents for local oral treatment
- A01A Stomatological preparations
- A02 Drugs for acid related disorders
- A02A Antacids
- A02B Drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
- A02BA H2-receptor antagonists
- A02BB Prostaglandins
- A02BC Proton pump inhibitors
- A02BD Combinations for eradication of Helicobacter pylori
- A02BX Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
- A02X Other drugs for acid related disorders
- A03 Drugs for functional gastrointestinal disorders
- A03A Drugs for functional bowel disorders
- A03AA Synthetic anticholinergics, esters with tertiary amino group
- A03AB Synthetic anticholinergics, quaternary ammonium compounds
- A03AC Synthetic antispasmodics, amides with tertiary amines
- A03AD Papaverine and derivatives
- A03AE Drugs acting on serotonin receptors
- A03AX Other drugs for functional bowel disorders
- A03B Belladonna and derivatives, plain
- A03BA Belladonna alkaloids, tertiary amines
- A03BB Belladonna alkaloids, semisynthetic, quaternary ammonium compounds
- A03C Antispasmodics in combination with psycholeptics
- A03CA Synthetic anticholinergic agents in combination with psycholeptics
- A03CB Belladonna and derivatives in combination with psycholeptics
- A03CC Other antispasmodics in combination with psycholeptics
- A03D Antispasmodics in combination with analgesics
- A03DA Synthetic anticholinergic agents in combination with analgesics
- A03DB Belladonna and derivatives in combination with analgesics
- A03DC Other antispasmodics in combination with analgesics
- A03E Antispasmodics and anticholinergics in combination with other drugs
- A03EA Antispasmodics, psycholeptics and analgesics in combination
- A03ED Antispasmodics in combination with other drugs
- A03F Propulsives
- A03FA Propulsives
- A03A Drugs for functional bowel disorders
- A04 Antiemetics and antinauseants
- A04A Antiemetics and antinauseants
- A04AA Serotonin (5HT3) antagonists
- A04AD Other antiemetics
- A04A Antiemetics and antinauseants
- A05 Bile and liver therapy
- A05A Bile therapy
- A05AA Bile acid preparations
- A05AB Preparations for biliary tract therapy
- A05AX Other drugs for bile therapy
- A05B Liver therapy, lipotropics
- A05BA Liver therapy
- A05C Drugs for bile therapy and lipotropics in combination
- A05A Bile therapy
- A06 Laxatives
- A06A Laxatives
- A06AA Softeners, emollients
- A06AB Contact laxatives
- A06AC Bulk producers
- A06AD Osmotically acting laxatives
- A06AG Enemas
- A06AX Other laxatives
- A06A Laxatives
- A07 Antidiarrheals, intestinal anti-inflammatory/anti-infective agents
- A07A Intestinal anti-infectives
- A07AA Antibiotics
- A07AB Sulfonamides
- A07AC Imidazole derivatives
- A07AX Other intestinal anti-infectives
- A07B Intestinal adsorbents
- A07BA Charcoal preparations
- A07BB Bismuth preparations
- A07BC Other intestinal adsorbents
- A07C Electrolytes with carbohydrates
- A07CA Oral rehydration salt formulations
- A07D Antipropulsives
- A07DA Antipropulsives
- A07E Intestinal anti-inflammatory agents
- A07EA Corticosteroids acting locally
- A07EB Antiallergic agents, excluding corticosteroids
- A07EC Aminosalicylic acid and similar agents
- A07F Antidiarrheal micro-organisms
- A07FA Antidiarrheal micro-organisms
- A07X Other antidiarrheals
- A07XA Other antidiarrheals
- A07A Intestinal anti-infectives
- A08 Antiobesity preparations, excluding diet products
- A08A Antiobesity preparations, excluding diet products
- A08AA Centrally acting antiobesity products
- A08AB Peripherally acting antiobesity products
- A08A Antiobesity preparations, excluding diet products
- A09 Digestives, including enzymes
- A09A Digestives, including enzymes
- A09AA Enzyme preparations
- A09AB Acid preparations
- A09AC Enzyme and acid preparations, combinations
- A09A Digestives, including enzymes
- A10 Drugs used in diabetes
- A10A Insulins and analogues
- A10AB Insulins and analogues, fast-acting
- A10AC Insulins and analogues, intermediate-acting
- A10AD Insulins and analogues, intermediate-acting combined with fast-acting
- A10AE Insulins and analogues, long-acting
- A10B Oral blood glucose lowering drugs
- A10BA Biguanides
- A10BB Sulfonamides, urea derivatives
- A10BC Sulfonamides (heterocyclic)
- A10BD Combinations of oral blood glucose lowering drugs
- A10BF Alpha glucosidase inhibitors
- A10BG Thiazolidinediones
- A10BX Other oral blood glucose lowering drugs
- A10X Other drugs used in diabetes
- A10XA Aldose reductase inhibitors
- A10A Insulins and analogues
- A11 Vitamins
- A11A Multivitamins, combinations
- A11AA Multivitamins with minerals
- A11B Multivitamins, plain
- A11BA Multivitamins, plain
- A11C Vitamin A and D, including combinations of the two
- A11CA Vitamin A, plain
- A11CB Vitamin A and D in combination
- A11CC Vitamin D and analogues
- A11D Vitamin B1, plain and in combination with vitamin B6 and B12
- A11DA Vitamin B1, plain
- A11DB Vitamin B1 in combination with vitamin B6 and/or vitamin B12
- A11E Vitamin B-complex, including combinations
- A11EA Vitamin B-complex, plain
- A11EB Vitamin B-complex with vitamin C
- A11EC Vitamin B-complex with minerals
- A11ED Vitamin B-complex with anabolic steroids
- A11EX Vitamin B-complex, other combinations
- A11G Ascorbic acid (vitamin C), including combinations
- A11GA Ascorbic acid (vitamin C), plain
- A11GB Ascorbic acid (vitamin C), combinations
- A11H Other plain vitamin preparations
- A11HA Other plain vitamin preparations
- A11J Other vitamin products, combinations
- A11JA Combinations of vitamins
- A11JB Vitamins with minerals
- A11JC Vitamins, other combinations
- A11A Multivitamins, combinations
- A12 Mineral supplements
- A13 Tonics
- A13A tonics
- A14 Anabolic agents for systemic use
- A15 Appetite stimulants
- A16 Other alimentary tract and metabolism products
- A16A Other alimentary tract and metabolism products
- A16AA Amino acids and derivatives
- A16AB Enzymes
- A16AX Various alimentary tract and metabolism products
- A16A Other alimentary tract and metabolism products
B Blood and blood forming organs
- B01 Antithrombotic agents
- B02 Antihemorrhagics
- B02A Antifibrinolytics
- B02AA Amino acids
- B02AB Proteinase inhibitors
- B02B Vitamin K and other hemostatics
- B02BA Vitamin K
- B02BB Fibrinogen
- B02BC Local hemostatics
- B02BD Blood coagulation factors
- B02BX Other systemic hemostatics
- B02A Antifibrinolytics
- B03 Antianemic preparations
- B03A Iron preparations
- B03AA Iron bivalent, oral preparations
- B03AB Iron trivalent, oral preparations
- B03AC Iron trivalent, parenteral preparations
- B03AD Iron in combination with folic acid
- B03AE Iron in other combinations
- B03B Vitamin B12 and folic acid
- B03BA Vitamin B12 (cyanocobalamin and analogues)
- B03BB Folic acid and derivatives
- B03X Other antianemic preparations
- B03XA Other antianemic preparations
- B03A Iron preparations
- B05 Blood substitutes and perfusion solutions
- B05A Blood and related products
- B05AA Blood substitutes and plasma protein fractions
- B05B I.V. Solutions
- B05BA Solutions for parenteral nutrition
- B05BB Solutions affecting the electrolyte balance
- B05BC Solutions producing osmotic diuresis
- B05C Irrigating solutions
- B05CA Anti-infectives
- B05CB Salt solutions
- B05CX Other irrigating solutions
- B05D Peritoneal dialytics
- B05DA Isotonic solutions
- B05DB Hypertonic solutions
- B05X I.V. Solution additives
- B05XA Electrolyte solutions
- B05XB Amino acids
- B05XC Vitamins
- B05XX Other I.V. solution additives
- B05Z Hemodialytics and hemofiltrates
- B05ZA Hemodialytics, concentrates
- B05ZB Hemofiltrates
- B05A Blood and related products
- B06 Other hematological agents
- B06A Other hematological agents
- B06AA Enzymes
- B06AB Other hematological products
- B06A Other hematological agents
C Cardiovascular system
- C01 Cardiac therapy
- C01A Cardiac glycosides
- C01AA Digitalis glycosides
- C01AB Scilla glycosides
- C01AC Strophantus glycosides
- C01AX Other cardiac glycosides
- C01B Antiarrhythmics, class I and III
- C01BA Antiarrhythmics, class Ia
- C01BB Antiarrhythmics, class Ib
- C01BC Antiarrhythmics, class Ic
- C01BD Antiarrhythmics, class III
- C01BG Other class I antiarrhythmics
- C01C Cardiac stimulants excluding cardiac glycosides
- C01CA Adrenergic and dopaminergic agents
- C01CE Phosphodiesterase inhibitors
- C01CX Other cardiac stimulants
- C01D Vasodilators used in cardiac diseases
- C01E Other cardiac preparations
- C01EA Prostaglandins
- C01EB Other cardiac preparations
- C01EX Other cardiac combination products
- C01A Cardiac glycosides
- C02 Antihypertensives
- C02A Antiadrenergic agents, centrally acting
- C02AA Rauwolfia alkaloids
- C02AB Methyldopa
- C02AC Imidazoline receptor agonists
- C02B Antiadrenergic agents, ganglion-blocking
- C02C Antiadrenergic agents, peripherally acting
- C02CA Alpha-adrenoreceptor antagonists
- C02CC Guanidine derivatives
- C02D Arteriolar smooth muscle, agents acting on
- C02DA Thiazide derivatives
- C02DB Hydrazinophthalazine derivatives
- C02DC Pyrimidine derivatives
- C02DD Nitroferricyanide derivatives
- C02DG Guanidine derivatives
- C02K Other antihypertensives
- C02L Antihypertensives and diuretics in combination
- C02LA Rauwolfia alkaloids and diuretics in combination
- C02LB Methyldopa and diuretics in combination
- C02LC Imidazoline receptor agonists in combination with diuretics
- C02LE Alpha-adrenoreceptor antagonists and diuretics
- C02LF Guanidine derivatives and diuretics
- C02LG Hydrazinophthalazine derivatives and diuretics
- C02LK Alkaloids, excluding rauwolfia, in combination with diuretics
- C02LL MAO inhibitors and diuretics
- C02LN Serotonin antagonists and diuretics
- C02LX Other antihypertensives and diuretics
- C02N Combinations of antihypertensives in ATC-group C02
- C02A Antiadrenergic agents, centrally acting
- C03 Diuretics
- C03A Low-ceiling diuretics, thiazides
- C03AA Thiazides, plain
- C03AB Thiazides and potassium in combination
- C03AH Thiazides, combinations with psycholeptics and/or analgesics
- C03AX Thiazides, combinations with other drugs
- C03B Low-ceiling diuretics, excluding thiazides
- C03BA Sulphonamides, plain
- C03BB Sulphonamides and potassium in combination
- C03BC Mercurial diuretics
- C03BD Xanthine derivatives
- C03BK Sulphonamides, combinations with other drugs
- C03BX Other low-ceiling diuretics
- C03C High-ceiling diuretics
- C03CA Sulphonamides, plain
- C03CB Sulphonamides and potassium in combination
- C03CC Aryloxyacetic acid derivatives
- C03CD Pyrazolone derivatives
- C03CX Other high-ceiling diuretics
- C03D Potassium-sparing agents
- C03DA Aldosterone antagonists
- C03DB Other potassium-sparing agents
- C03E Diuretics and potassium-sparing agents in combination
- C03EA Low-ceiling diuretics and potassium-sparing agents
- C03EB High-ceiling diuretics and potassium-sparing agents
- C03A Low-ceiling diuretics, thiazides
- C04 Peripheral vasodilators
- C04A Peripheral vasodilators
- C04AA 2-amino-1-phenylethanol derivatives
- C04AB Imidazoline derivatives
- C04AC Nicotinic acid and derivatives
- C04AD Purine derivatives
- C04AE Ergot alkaloids
- C04AF Enzymes
- C04AX Other peripheral vasodilators
- C04A Peripheral vasodilators
- C05 Vasoprotectives
- C05A Antihemorrhoidals for topical use
- C05AA Products containing corticosteroids
- C05AB Products containing antibiotics
- C05AD Products containing local anesthetics
- C05AX Other antihemorrhoidals for topical use
- C05B Antivaricose therapy
- C05BA Heparins or heparinoids for topical use
- C05BB Sclerosing agents for local injection
- C05BX Other sclerosing agents
- C05C Capillary stabilising agents
- C05CA Bioflavonoids
- C05CX Other capillary stabilising agents
- C05A Antihemorrhoidals for topical use
- C07 Beta blocking agents
- C07A Beta blocking agents
- C07AA Beta blocking agents, non-selective
- C07AB Beta blocking agents, selective
- C07AG Alpha and beta blocking agents
- C07B Beta blocking agents and thiazides
- C07BA Beta blocking agents, non-selective, and thiazides
- C07BB Beta blocking agents, selective, and thiazides
- C07BG Alpha and beta blocking agents and thiazides
- C07C Beta blocking agents and other diuretics
- C07CA Beta blocking agents, non-selective, and other diuretics
- C07CB Beta blocking agents, selective, and other diuretics
- C07CG Alpha and beta blocking agents and other diuretics
- C07D Beta blocking agents, thiazides and other diuretics
- C07DA Beta blocking agents, non-selective, thiazides and other diuretics
- C07DB Beta blocking agents, selective, thiazides and other diuretics
- C07E Beta blocking agents and vasodilators
- C07EA Beta blocking agents, non-selective, and vasodilators
- C07EB Beta blocking agents, selective, and vasodilators
- C07F Beta blocking agents and other antihypertensives
- C07FA Beta blocking agents, non-selective, and other antihypertensives
- C07FB Beta blocking agents, selective, and other antihypertensives
- C07A Beta blocking agents
- C08 Calcium channel blockers
- C08C Selective calcium channel blockers with mainly vascular effects
- C08CA Dihydropyridine derivatives
- C08CX Other selective calcium channel blockers with mainly vascular effects
- C08D Selective calcium channel blockers with direct cardiac effects
- C08DA Phenylalkylamine derivatives
- C08DB Benzothiazepine derivatives
- C08E Non-selective calcium channel blockers
- C08EA Phenylalkylamine derivatives
- C08EX Other non-selective calcium channel blockers
- C08G Calcium channel blockers and diuretics
- C08GA Calcium channel blockers and diuretics
- C08C Selective calcium channel blockers with mainly vascular effects
- C09 Agents acting on the renin-angiotensin system
- C09A ACE inhibitors, plain
- C09AA ACE inhibitors, plain
- C09B ACE inhibitors, combinations
- C09BA ACE inhibitors and diuretics
- C09BB ACE inhibitors and calcium channel blockers
- C09C Angiotensin II antagonists, plain
- C09CA Angiotensin II antagonists, plain
- C09D Angiotensin II antagonists, combinations
- C09DA Angiotensin II antagonists and diuretics
- C09X Other agents acting on the renin-angiotensin system
- C09XA Renin-inhibitors
- C09A ACE inhibitors, plain
- C10 Serum lipid reducing agents
- C10A Cholesterol and triglyceride reducers
- C10AA HMG CoA reductase inhibitors
- C10AB Fibrates
- C10AC Bile acid sequestrants
- C10AD Nicotinic acid and derivatives
- C10AX Other cholesterol and triglyceride reducers
- C10A Cholesterol and triglyceride reducers
D Dermatologicals
- D01 Antifungals for dermatological use
- D01A Antifungals for topical use
- D01AA Antibiotics
- D01AC Imidazole and triazole derivatives
- D01AE Other antifungals for topical use
- D01B Antifungals for systemic use
- D01BA Antifungals for systemic use
- D01A Antifungals for topical use
- D02 Emollients and protectives
- D02A Emollients and protectives
- D02AA Silicone products
- D02AB Zinc products
- D02AC Soft paraffin and fat products
- D02AD Liquid plasters
- D02AE Carbamide products
- D02AF Salicylic acid preparations
- D02AX Other emollients and protectives
- D02B Protectives against UV-radiation
- D02BA Protectives against UV-radiation for topical use
- D02BB Protectives against UV-radiation for systemic use
- D02A Emollients and protectives
- D03 Preparations for treatment of wounds and ulcers
- D03A Cicatrizants
- D03AA Cod-liver oil ointments
- D03AX Other cicatrizants
- D03B Enzymes
- D03BA Proteolytic enzymes
- D03A Cicatrizants
- D04 Antipruritics, including antihistamines, anesthetics, etc.
- D04A Antipruritics, including antihistamines, anesthetics, etc.
- D04AA Antihistamines for topical use
- D04AB Anesthetics for topical use
- D04AX Other antipruritics
- D04A Antipruritics, including antihistamines, anesthetics, etc.
- D05 Antipsoriatics
- D05A Antipsoriatics for topical use
- D05B Antipsoriatics for systemic use
- D06 Antibiotics and chemotherapeutics for dermatological use
- D06A Antibiotics for topical use
- D06AA Tetracycline and derivatives
- D06AX Other antibiotics for topical use
- D06B Chemotherapeutics for topical use
- D06BA Sulphonamides
- D06BB Antivirals
- D06BX Other chemotherapeutics
- D06C Antibiotics and chemotherapeutics, combinations
- D06A Antibiotics for topical use
- D07 Corticosteroids, dermatological preparations
- D07A Corticosteroids, plain
- D07AA Corticosteroids, weak (group I)
- D07AB Corticosteroids, moderately potent (group II)
- D07AC Corticosteroids, potent (group III)
- D07AD Corticosteroids, very potent (group IV)
- D07B Corticosteroids, combinations with antiseptics
- D07BA Corticosteroids, weak, combinations with antiseptics
- D07BB Corticosteroids, moderately potent, combinations with antiseptics
- D07BC Corticosteroids, potent, combinations with antiseptics
- D07BD Corticosteroids, very potent, combinations with antiseptics
- D07C Corticosteroids, combinations with antibiotics
- D07CA Corticosteroids, weak, combinations with antibiotics
- D07CB Corticosteroids, moderately potent, combinations with antibiotics
- D07CC Corticosteroids, potent, combinations with antibiotics
- D07CD Corticosteroids, very potent, combinations with antibiotics
- D07X Corticosteroids, other combinations
- D07XA Corticosteroids, weak, other combinations
- D07XB Corticosteroids, moderately potent, other combinations
- D07XC Corticosteroids, potent, other combinations
- D07XD Corticosteroids, very potent, other combinations
- D07A Corticosteroids, plain
- D08 Antiseptics and disinfectants
- D08A Antiseptics and disinfectants
- D08AA Acridine derivatives
- D08AB Aluminium agents
- D08AC Biguanides and amidines
- D08AD Boric acid products
- D08AE Phenol and derivatives
- D08AF Nitrofuran derivatives
- D08AG Iodine products
- D08AH Quinoline derivatives
- D08AJ Quaternary ammonium compounds
- D08AK Mercurial products
- D08AL Silver compounds
- D08AX Other antiseptics and disinfectants
- D08A Antiseptics and disinfectants
- D09 Medicated dressings
- D09A Medicated dressings
- D09AA Ointment dressings with anti-infectives
- D09AB Zinc bandages
- D09AX Soft paraffin dressings
- D09A Medicated dressings
- D10 Anti-acne preparations
- D10A Anti-acne preparations for topical use
- D10B Anti-acne preparations for systemic use
- D10BA Retinoids for treatment of acne
- D10BX Other anti-acne preparations for systemic use
- D11 Other dermatological preparations
- D11A Other dermatological preparations
- D11AA Antihidrotics
- D11AC Medicated shampoos
- D11AE Androgens for topical use
- D11AF Wart and anti- corn preparations
- D11AX Other dermatologicals
- D11A Other dermatological preparations
G Genito-urinary system and sex hormones
- G01 Gynecological anti-infectives and antiseptics
- G01A Anti-infectives and antiseptics, excluding combinations with corticosteroids
- G01AA Antibiotics
- G01AB Arsenic compounds
- G01AC Quinoline derivatives
- G01AD Organic acids
- G01AE Sulphonamides
- G01AF Imidazole derivatives
- G01AG Triazole derivatives
- G01AX Other anti-infectives and antiseptics
- G01B Anti-infectives/antiseptics in combination with corticosteroids
- G01BA Antibiotics and corticosteroids
- G01BC Quinoline derivatives and corticosteroids
- G01BD Antiseptics and corticosteroids
- G01BE Sulphonamides and corticosteroids
- G01BF Imidazole derivatives and corticosteroids
- G01A Anti-infectives and antiseptics, excluding combinations with corticosteroids
- G02 Other gynecologicals
- G02A Oxytocics
- G02AB Ergot alkaloids
- G02AC Ergot alkaloids and oxytocin including analogues, in combination
- G02AD Prostaglandins
- G02AX Other oxytocics
- G02B Contraceptives for topical use
- G02BA Intrauterine contraceptives
- G02BB Intravaginal contraceptives
- G02C Other gynecologicals
- G02CA Sympathomimetics, labour repressants
- G02CB Prolactine inhibitors
- G02CC Anti-inflammatory products for vaginal administration
- G02CX Other gynecologicals
- G02A Oxytocics
- G03 Sex hormones and modulators of the genital system
- G03A Hormonal contraceptives for systemic use
- G03AA Progestogens and estrogens, fixed combinations
- G03AB Progestogens and estrogens, sequential preparations
- G03AC Progestogens
- G03B Androgens
- G03BA 3-oxoandrosten-(4) derivatives
- G03BB 5-androstanon-(3) derivatives
- G03C Estrogens
- G03CA Natural and semisynthetic estrogens, plain
- G03CB Synthetic estrogens, plain
- G03CC Estrogens, combinations with other drugs
- G03D Progestogens
- G03DA Pregnen-(4) derivatives
- G03DB Pregnadien derivatives
- G03DC Estren derivatives
- G03E Androgens and female sex hormones in combination
- G03EA Androgens and estrogens
- G03EB Androgen, progestogen and estrogen in combination
- G03EK Androgens and female sex hormones in combination with other drugs
- G03F Progestogens and estrogens in combination
- G03FA Progestogens and estrogens, fixed combinations
- G03FB Progestogens and estrogens, sequential preparations
- G03G Gonadotropins and other ovulation stimulants
- G03GA Gonadotropins
- G03GB Ovulation stimulants, synthetic
- G03H Antiandrogens
- G03HA Antiandrogens, plain
- G03HB Antiandrogens and estrogens
- G03X Other sex hormones and modulators of the genital system
- G03XA Antigonadotropins and similar agents
- G03XB Antiprogestogens
- G03XC Selective estrogen receptor modulators
- G03A Hormonal contraceptives for systemic use
- G04 Urologicals
- G04B Other urologicals, incl. antispasmodics
- G04BA Acidifiers
- G04BC Urinary concrement solvents
- G04BD Urinary antispasmodics
- G04BE Drugs used in erectile dysfunction
- G04BX Other urologicals
- G04C Drugs used in benign prostatic hypertrophy
- G04CA Alpha-adrenoreceptor antagonists
- G04CB Testosterone-5-alpha reductase inhibitors
- G04CX Other drugs used in benign prostatic hypertrophy
- G04B Other urologicals, incl. antispasmodics