Captopril challenge test
In medicine, the captopril challenge test, also CCT, is procedure used to diagnose renal artery stenosis. It is performed by measuring the renin prior to and following the administration of captopril, an angiotensin converting enzyme inhibitor. A CCT is considered positive if the renin levels increase substaintially or the baseline renin level is abnormally high.[1]
It is a non-invasive test that has a high sensitivity, but a low specificity.[2] A better test for diagnosing renal artery stenosis is subtraction renal angiography.[3]
The CCT has no been found to be very useful in children.[4]
References
- ^ Muller FB, Sealey JE, Case DB, Atlas SA, Pickering TG, Pecker MS, Preibisz JJ, Laragh JH. The captopril test for identifying renovascular disease in hypertensive patients. Am J Med. 1986 Apr;80(4):633-44. PMID 3515933.
- ^ Bales A. Hypertensive crisis. How to tell if it's an emergency or an urgency. Postgrad Med. 1999 May 1;105(5):119-26, 130. PMID 10335324. Free Full Text
- ^ Svetkey LP, Himmelstein SI, Dunnick NR, Wilkinson RH Jr, Bollinger RR, McCann RL, Beytas EM, Klotman PE. Prospective analysis of strategies for diagnosing renovascular hypertension. Hypertension. 1989 Sep;14(3):247-57. PMID 2670763.
- ^ Gauthier B, Trachtman H, Frank R, Pillari G. Inadequacy of captopril challenge test for diagnosing renovascular hypertension in children and adolescents. Pediatr Nephrol. 1991 Jan;5(1):42-4. PMID 2025535.
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