PYLIS downstream sequence
In biology, the PYLIS downstream sequence (PYLIS: pyrrolysine insertion sequence) is a stem-loop structure which appears on some mRNA sequences. This structural motif causes the UAG (amber) stop codon to be translated to the amino acid pyrrolysine instead of ending the protein translation. In archaea the PYLIS downstream sequence is positioned straight after the UAG codon which is translated as pyrrolysine.[1][2]
References
- ^ Théobald-Dietrich A, Giegé R, Rudinger-Thirion J (2005). "Evidence for the existence in mRNAs of a hairpin element responsible for ribosome dependent pyrrolysine insertion into proteins". Biochimie. 87 (9–10): 813–7. doi:10.1016/j.biochi.2005.03.006. PMID 16164991.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Zhang Y, Baranov PV, Atkins JF, Gladyshev VN (2005). "Pyrrolysine and selenocysteine use dissimilar decoding strategies". J. Biol. Chem. 280 (21): 20740–51. doi:10.1074/jbc.M501458200. PMID 15788401.
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Further reading
- Longstaff DG, Blight SK, Zhang L, Green-Church KB, Krzycki JA (2007). "In vivo contextual requirements for UAG translation as pyrrolysine". Mol. Microbiol. 63 (1): 229–41. doi:10.1111/j.1365-2958.2006.05500.x. PMID 17140411.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - Namy O, Zhou Y, Gundllapalli S; et al. (2007). "Adding pyrrolysine to the Escherichia coli genetic code". FEBS Lett. 581 (27): 5282–8. doi:10.1016/j.febslet.2007.10.022. PMID 17967457.
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