Bootstrap error-adjusted single-sample technique
In statistics, the bootstrap error-adjusted single-sample technique (BEST) is a non-parametric method for estimating the distribution of a sample.[1] It is based on a statistical method called bootstrapping. BEST provides advantages over other methods such as the Mahalanobis metric, because it does not assume equal covariance for all spectral groups[clarification needed] or that each group is drawn for a normally distributed population.[2]
Application
BEST is used in detection of sample tampering in pharmaceutical products. Valid (unaltered) samples are defined as those that fall inside the cluster of training-set points when the BEST is trained with unaltered product samples. False (tampered) samples are those that fall outside of the same cluster.[1]
References
- ^ a b Lodder, R.A.; Selby, M.; Hieftje, G.A. (1987) Anal. Chem., 59, (15), 1921–1930 [full citation needed]
- ^ Efron, B.; Gong, G. (1983) American Statistician, 37 (1), 36–48 [full citation needed]
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