Histone 3′ UTR stem-loop

Histone 3′ UTR stem-loop
Identifiers
Other data
PDB structures	PDBe

The Histone 3' UTR stem-loop is an RNA element involved in nucleocytoplasmic transport of the mRNA, and in stability regulation and translation efficiency in the cytoplasm. The mRNAs of metazoan histone genes lack a poly-A tail. 3' end processing occurs at a site between this highly conserved stem-loop and a purine rich region around 20 nucleotides downstream (the histone downstream element, or HDE). The stem-loop is bound by a 31 kDa stem-loop binding protein (SLBP - also termed the histone hairpin binding protein, or HBP). Together with U7 snRNA binding of the HDE, SLBP binding nucleates the formation of the processing complex.

References

• [1] Williams, AS (1995). "The sequence of the stem and flanking sequences at the 3' end of histone mRNA are critical determinants for the binding of the stem-loop binding protein". Nucleic Acids Res. 23 (4): 654–662. doi:10.1093/nar/23.4.654. PMC 306734. PMID 7899087. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
• [2] Dominski, Z (1999). "Formation of the 3' end of histone mRNA". Gene. 239 (1): 1–14. doi:10.1016/S0378-1119(99)00367-4. PMID 10571029. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

External links

• Page for Histone 3' UTR stem-loop at Rfam
• Transterm page for Histone 3' stem loop
• UTRSite page for Histone 3'UTR stem-loop structure (HSL3)