Vascular-targeting agent
A vascular-targeting agent (VTA) or vascular disrupting agent (VDA) is a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.[1]
VTAs can be small-molecule or ligand-based.
Small-molecule VTAs include:
- microtubule destabilizing drugs such as combretastatin A-4 disodium phosphate (CA4P), ZD6126, AVE8062, Oxi 4503
- vadimezan (ASA404)
Clinical trials
Phase II : ZD6126, CA4P, NPI-2358[2]
Phase III : DMXAA (ASA404).
References
- ^ "Vascular Targeting Agents as Cancer Therapeutics" (PDF). 2004.
{{cite journal}}: Cite journal requires|journal=(help) - ^ Conducted by Nereus Pharmaceuticals.
Staff (2009), "Clinical Trials Update", Genetic Engineering & Biotechnology News, 29 (8): 58
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