Progress zone
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The progress zone is a layer of mesodermal cells immediately beneath the apical ectodermal ridge in the developing limb bud. The fate of the mesodermal cells is thought to be patterned by the length of time spent in the progress zone during limb outgrowth [Ref 1]. However, some recent evidence using microinjected embryos suggests that the cells are prespecified early in limb bud development [Ref 2].
References
- ^ Summerbell, D., Lewis, J. H., & Wolpert, L. (1973). Positional Information in Chick Limb Morphogenesis. Nature, 244, 492 - 496. http://dx.doi.org/10.1038/244492a0.
- ^ Dudley, A. T., Ros, M. A., & Tabin, C. (2002). A re-examination of proximodistal patterning during vertebrate limb development. Nature, 418(August), 539-544. http://dx.doi.org/10.1038/nature00906.1.
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