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PyBOP

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PyBOP
Names
IUPAC name
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Other names
PyBOP
Identifiers
3D model (JSmol)
ECHA InfoCard 100.125.168 Edit this at Wikidata
  • c1cccc5c1nnn5O[P+](N2CCCC2)(N3CCCC3)N4CCCC4
Properties
C18H28N6OP·PF6
Molar mass 520.39 g/mol
Appearance White crystals
Melting point 150 °C
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Irritant
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

PyBOP is the common name for the chemical benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate, a peptide coupling reagent used in solid phase peptide synthesis. It is used as a substitute for the BOP reagent, thus avoiding the formation of the carcinogenic side product HMPA.

See also

  • BOP reagent (Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate)