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Duck HBV RNA encapsidation signal epsilon

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Duck HBV RNA encapsidation signal epsilon
Identifiers
Other data
PDB structuresPDBe

The Duck HBV RNA encapsidation signal epsilon is an RNA structure that is shown to facilitate encapsidation of the pregenomic RNA required for replication.

DHBV is used as a model to understand human HBV. DHBV epsilon consists of a stem structure, a bulge and an apical stem loop. The RNA structure was determined by chemical probing, NMR analysis and by mutagenesis [1].

A recent NMR analysis of the DHBV epsilon have shown that the apical loop to be capped by a stable well-structured UGUU tetraloop [2].

The Rfam structure is based on a covariation model.

References

  1. ^ Smith Gj, 3rd; Donello, JE; Lück, R; Steger, G; Hope, TJ (1998). "The hepatitis B virus post-transcriptional regulatory element contains two conserved RNA stem-loops which are required for function". Nucleic acids research. 26 (21): 4818–27. PMC 147918. PMID 9776740.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  2. ^ Girard, FC; Ottink, OM; Ampt, KA; Tessari, M; Wijmenga, SS (2007). "Thermodynamics and NMR studies on Duck, Heron and Human HBV encapsidation signals". Nucleic acids research. 35 (8): 2800–11. doi:10.1093/nar/gkm131. PMC 1885660. PMID 17430968.

HBV RNA encapsidation signal epsilon

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