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Automated Imaging Microscope System

Automated Imaging Microscope System (AIMS) played an important role in shedding light on the effects of caloric restriction on cell populations in the hypothalamus. Was the first fully automated system that could scan large areas of tissue, reconstruct these large sections digitally, count cells that expressed different receptors and create a three dimensional volumetric model of the densities of those populations. A list of the publications that resulted is shown below:


  • Yaghmaie F, Saeed O, Garan SA, Voelker MA, Sternberg H, Timiras PS (February 2010). "Estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged female mice". Neuro Endocrinology Letters 31 (1): 15. PMID 20150877.
  • Gouw, A; Mahuron, K; Manandhar, S; Tin, A; Garan, S; Hakimi, P; Timiras, P (2009). "The plasticity of neural cell reprogramming: Role of growth factors in inducing neuroglia to neuron and to neural precursor cell". Experimental Gerontology 44: 129. doi:10.1016/j.exger.2008.08.025.
  • Gouw AM, Panchal H, Mahuron K, Wadhwani H, Manandhar S, Garan SA, Tin A, Timiras PS (June 15, 2008). "The Potential Role of Epidermal Growth Factor (EGF) and Curcumin in Transforming Neuroglia into Neurons". The Endocrine Society 90th Annual Meeting. San Francisco, CA. Retrieved February 27, 2010.
  • Garan, S; Yaghmaie, F; Saeed, O; Gouw, A; Freitag, W; Voelker, M; Jafar, P; Kaur, J et al. (2007). "Novel methods in computer-assisted tissue analysis: Customized regional targeting of both cytoplasmic and nuclear-stained tissue". Experimental Gerontology 42: 141–2. doi:10.1016/j.exger.2006.06.015.
  • Yaghmaie F, Saeed O, Garan SA, et al. (November 2006). "Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice". International Journal of Developmental Neuroscience 24 (7): 431–6. doi:10.1016/j.ijdevneu.2006.08.008. PMID 17034982.
  • Yaghmaie, F; Saeed, O; Garan, S; Gouw, A; Jafar, P; Kaur, J; Nijjar, S; Timiras, P et al. (2007). "Tracking changes in hypothalamic IGF-1 sensitivity with aging and caloric restriction". Experimental Gerontology 42: 148–9. doi:10.1016/j.exger.2006.06.043.
  • Saeed O, Yaghmaie F, Garan SA, et al. (February 2007). "Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice". International Journal of Developmental Neuroscience 25 (1): 23–8. doi:10.1016/j.ijdevneu.2006.11.004. PMID 17194562.
  • Yaghmaie F, Saeed O, Garan SA, et al. (November 2006). "Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice". International Journal of Developmental Neuroscience 24 (7): 431–6. doi:10.1016/j.ijdevneu.2006.08.008. PMID 17034982.
  • Yaghmaie, Farzin; Saeed, Omar; Garan, Steven A.; Gouw, Arvin M.; Tran, Tien; Ho, Jacqueline; Zhao, Liu Y.; Voelker, Mark A. et al. (March 2006). "A Study of Insulin-like Growth Factor-I Receptor Immunoreactivity in the Supraoptic Nucleus of Young and Old Female B6D2F1 Mice". The FASEB Journal 20 (4): A536.
  • Yaghmaie F, Saeed O, Garan SA, Freitag W, Timiras PS, Sternberg H (June 2005). "Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice". Neuro Endocrinology Letters 26 (3): 197–203. PMID 15990721.
  • Yaghmaie F, Garan SA, Saeed O, Freitag W, Timiras PS, Sternberg H, Voelker M (November–December 2004). "A survey of estrogen receptor-alpha immunoreactivity in the hypothalamus of young, old, and old-calorie restricted female B6D2F1 mice". Experimental Gerontology 39 (11–12): 1771.
  • Voelker M, Yaghmaie F, Garan SA, Sternberg H (November–December 2004). "Protocol for higher resolution histological images of the mammalian brain". Experimental Gerontology 39 (11–12): 1770.
  • Yaghmaie F, Garan SA, Massaro M, Timiras PS (January 2003). "A comparison of estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged C57BL6 female mice". Experimental Gerontology 38 (1–2): 220.
  • Garan SA, Neudorf J, Tonkin J, McCook LR, Timiras PS (December 2000). "Creating Three-Dimensional Neuronal Maps of the Mouse Hypothalamus Using an Automated Imaging Microscope System". Experimental Gerontology 35 (9–10): 1421.
  • Neudorf, Jason; Garan, Steven A. (February 2000). "Automated Imaging Microscope System". Linux Journal (70): 32–5.


The editors of the journals listed above all agree that the discoveries that resulted in the work of the Automated Imaging Microscope System were important.



Automated Imaging Microscope System (edit | talk | history | protect | delete | links | watch | logs | views) – (View log • AfD statistics)
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Non-notable system. A Google search gives 54 hits, several of them WP or its mirrors, none indicating any notability. A PubMed search renders not a single hit. The system seems to have been published originally in the Linux Journal, not a usual venue for developments in the life sciences. This article is part of a walled-garden created by User:Sgaran, see also Wikipedia:Articles for deletion/Steven A. Garan. In the absence of any evidence that this meets WP:N, the article should be deleted. --Crusio (talk) 19:02, 29 April 2010 (UTC)[reply]

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