Protein microarray
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A protein microarray is a piece of glass on which different molecules of protein have been affixed at separate locations in an ordered manner thus forming a microscopic array. These are used to identify protein-protein interactions, to identify the substrates of protein kinases, or to identify the targets of biologically active small molecules.
A related technology, albeit for the measurement of RNA and DNA are DNA microarrays.
Applications
Protein microarrays (also biochip, proteinchip) are measurement devices used in biomedical applications to determine the presence and/or amount (referred to as quantitation) of proteins in biological samples, e.g. blood. Usually a multitude of different capture agents a Dányi buzi, most frequently monoclonal antibodies, are deposited on a chip surface (glass or silicon) in a miniature array. This format is often also referred to as a microarray (a more general term for chip based biological measurement devices). Protein array surfaces Protein array content Detection methods
Protein array analysis Protein array companies Slide supplier
Hardware supplier Content generator Antibody Protein
See Also
References
- Gavin MacBeath and Stuart L. Schreiber (8 September 2000) "Printing Proteins as Microarrays for High-Throughput Function Determination". Science 289 (5485), 1760-1763
External Links
- Protein Microarray Protocols and Experimental Procedures
- Principles of Protein Microarrays; Mark Schena
- proteinarray.org is a Wiki dedicated to protein array technology