Fusion transcript
Fusion transcript is a chimeric RNA encoded by a fusion gene[1] or by two different genes by subsequent trans-splicing.[2][3] Certain fusion transcripts are commonly produced by cancer cells, and detection of fusion transcripts is part of routine diagnostics of certain caner types.
References
- ^ Mitelman (2007). "The impact of translocations and gene fusions on cancer causation". Nature reviews. Cancer. 7 (4): 233–45. doi:10.1038/nrc2091. PMID 17361217.
{{cite journal}}:|first2=missing|last2=(help);|first3=missing|last3=(help) - ^ Li (2008). "A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells". Science (New York, N.Y.). 321 (5894): 1357–61. doi:10.1126/science.1156725. PMID 18772439.
{{cite journal}}:|first2=missing|last2=(help);|first3=missing|last3=(help);|first4=missing|last4=(help) - ^ Rickman (2009). "SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer". Cancer research. 69 (7): 2734–8. doi:10.1158/0008-5472.CAN-08-4926. PMID 19293179.
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