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Dimethyl pimelimidate

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Dimethyl pimelimidate dihydrochloride
File:Dimethyl pimelimidate dihydrochloride.svg
Names
IUPAC name
1,7-dimethoxyheptane-1,7-diimine dihydrochloride
Other names
Pimelimidic acid dimethyl ester dihydrochloride,
dimethyl heptane-1,7-diimidate dihydrochloride
Identifiers
3D model (JSmol)
  • COC(=N)CCCCCC(=N)OC.Cl.Cl
Properties
[CH3OC(=NH)CH2CH2]2CH2 · 2HCl
Molar mass 259.17 g/mol
Appearance white crystalline powder
Melting point 122 °C
Slightly soluble
Hazards
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
1
1
0
Flash point Not determined
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Dimethyl pimelimidate dihydrochloride (IUPAC systematic name: 1,7-dimethoxyheptane-1,7-diimine dihydrochloride) (often abbreviated as DMP), is an organic chemical compound with two functional imine groups, which both bind to free amino groups at pH range 7.0-10.0 to form amidine bonds.

Uses

DMP is used mainly as bifunctional coupling reagent to link proteins. It is often used to prepare antibody affinity columns. The appropriate antibody is first incubated with Protein A or Protein G-agarose and allowed to bind. DMP is then added to couple the molecules together.

Health effects

Dimethyl pimelimidate (DMP) is irritating to the eyes, skin, mucous membranes and upper respiratory tract. It can exert harmful effects by inhalation, ingestion, or skin absorption.

References

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