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Activating transcription factor 2

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Template:PBB Activating transcription factor 2, also known as ATF2, is a human gene.[1]

Template:PBB Summary

The gene atf2 is located at human chromosome 2q32[2]. The protein ATF-2 has 505 amino acids. Studies in mice indicate a role for ATF-2 in the development of nervous system and the skeleton[3]. ATF-2 is normally activated in response to signals that converge on stress-activated protein kinases p38 and JNK[4]. Several studies implicate abnormal activation of ATF-2 in growth and progression of mammalian skin tumors[5][6]. ATF-2 may mediate oncogenesis caused by mutant Ras protein[7] and regulate maintenance of the aggressive cancer phenotype of some types of epithelial cells.

Interactions

Activating transcription factor 2 has been shown to interact with NCOA6,[8] RUVBL2,[9] CSNK2A2,[10] MAPK14,[11][12][13] Casein kinase 2, alpha 1, JDP2 (gene),[14] MAPK8,[15] CREB binding protein,[16] C-jun and UBE2I.[17][18][19][20]

See also

References

  1. ^ "Entrez Gene: ATF2 activating transcription factor 2".
  2. ^ Ozawa K, Sudo T, Soeda E, Yoshida MC, Ishii S (1991). "Assignment of the human CREB2 (CRE-BP1) gene to 2q32". Genomics. 10 (4): 1103–4. doi:10.1016/0888-7543(91)90210-6. PMID 1833307.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Reimold AM, Grusby MJ, Kosaras B; et al. (1996). "Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice". Nature. 379 (6562): 262–5. doi:10.1038/379262a0. PMID 8538792. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  4. ^ Gupta S, Campbell D, Dérijard B, Davis RJ (1995). "Transcription factor ATF2 regulation by the JNK signal transduction pathway". Science. 267 (5196): 389–93. doi:0.1126/science.7824938. PMID 7824938. {{cite journal}}: Check |doi= value (help)CS1 maint: multiple names: authors list (link)
  5. ^ Leslie MC, Bar-Eli M (2005). "Regulation of gene expression in melanoma: new approaches for treatment". J. Cell. Biochem. 94 (1): 25–38. doi:10.1002/jcb.20296. PMID 15523674.
  6. ^ Papassava P, Gorgoulis VG, Papaevangeliou D, Vlahopoulos S, van Dam H, Zoumpourlis V (2004). "Overexpression of activating transcription factor-2 is required for tumor growth and progression in mouse skin tumors". Cancer Res. 64 (23): 8573–84. doi:10.1158/0008-5472.CAN-03-0955. PMID 15574764.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ^ Vlahopoulos SA, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V (2008-03-17). "The role of ATF-2 in oncogenesis". Bioessays. 30 (4): 314–327. doi:10.1002/bies.20734. PMID 18348191.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ Hong, SunHwa (2004). "Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid". J. Biol. Chem. 279 (17). United States: 16996–7003. doi:10.1074/jbc.M311752200. ISSN 0021-9258. PMID 14734562. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  9. ^ Cho, S G (2001). "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage". Mol. Cell. Biol. 21 (24). United States: 8398–413. doi:10.1128/MCB.21.24.8398-8413.2001. ISSN 0270-7306. PMID 11713276. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  10. ^ Yamaguchi, Y (1998). "Casein kinase II interacts with the bZIP domains of several transcription factors". Nucleic Acids Res. 26 (16). ENGLAND: 3854–61. ISSN 0305-1048. PMID 9685505. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  11. ^ Raingeaud, J (1995). "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine". J. Biol. Chem. 270 (13). UNITED STATES: 7420–6. ISSN 0021-9258. PMID 7535770. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  12. ^ Chen, Z (2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. 276 (19). United States: 16070–5. doi:10.1074/jbc.M100681200. ISSN 0021-9258. PMID 11279118. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  13. ^ Tournier, C (1997). "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. 94 (14). UNITED STATES: 7337–42. ISSN 0027-8424. PMID 9207092. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  14. ^ Murata, Takehide (2008). "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1". Anal. Biochem. 376 (1). United States: 115–21. doi:10.1016/j.ab.2008.01.038. PMID 18307971. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  15. ^ Fuchs, S Y (1997). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors". J. Biol. Chem. 272 (51). UNITED STATES: 32163–8. ISSN 0021-9258. PMID 9405416. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  16. ^ Sano, Y (1998). "CBP alleviates the intramolecular inhibition of ATF-2 function". J. Biol. Chem. 273 (44). UNITED STATES: 29098–105. ISSN 0021-9258. PMID 9786917. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  17. ^ Newell, C L (1994). "Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene". J. Leukoc. Biol. 56 (1). UNITED STATES: 27–35. ISSN 0741-5400. PMID 8027667. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  18. ^ Kara, C J (1990). "A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain". Mol. Cell. Biol. 10 (4). UNITED STATES: 1347–57. ISSN 0270-7306. PMID 2320002. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  19. ^ Hai, T (1991). "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity". Proc. Natl. Acad. Sci. U.S.A. 88 (9). UNITED STATES: 3720–4. ISSN 0027-8424. PMID 1827203. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  20. ^ Firestein, R (1998). "Association of activating transcription factor 2 (ATF2) with the ubiquitin-conjugating enzyme hUBC9. Implication of the ubiquitin/proteasome pathway in regulation of ATF2 in T cells". J. Biol. Chem. 273 (10). UNITED STATES: 5892–902. ISSN 0021-9258. PMID 9488727. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)

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