CLASP1
Template:PBB Cytoplasmic linker associated protein 1, also known as CLASP1 is a protein which in humans is encoded by the CLASP1 gene.[1]
Function
CLASP1 belongs to a family of microtubule-associated proteins involved in attachment of microtubules to the cell cortex in animals[2] and plants.[3] CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle.[4][1]
References
- ^ a b "Entrez Gene: CLASP1 cytoplasmic linker associated protein 1".
- ^ Lansbergen G, Grigoriev I, Mimori-Kiyosue Y; et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Developmental Cell. 11: 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ Ambrose JC, Wasteneys GO (2008). "Clasp modulates microtubule-cortex interaction during self organization of acentrosomal microtubules". Molecular Biology of the Cell. 19: 4730–4737. doi:10.1091/mbc.E08-06-0665. PMID 18716054.
- ^ Maiato H, Fairley EA, Rieder CL, Swedlow JR, Sunkel CE, Earnshaw WC (2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. PMID 12837247.
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Further reading
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