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Anchor cell
The anchor cell is a cell in nematodes such as Caenorhabditis elegans. It is important in the development of the reproductive system, as it is required for the production of the tube of cells that allows embryos to pass from the uterus through the vulva to the outside of the worm.
During the development of C. elegans hermaphrodites, the anchor cell produces a signalling molecule (LIN-3/EGF) that induces nearby epidermal cells to develop into the vulva.[1] The anchor cell also produces another signal (the Notch ligand LAG-2) that induces adjacent uterine cells to become the π cells,[2] some of which will later connect the uterus to the vulva.[3] The anchor cell next removes the basement membrane that separates the uterus and vulva and invades, which initiates the connection between the uterus and the vulva.[4] Finally the anchor cell fuses with eight of the π cells to form the uterine seam cell.[3]
References
- ^ Hill RJ, Sternberg PW (1992). "The gene lin-3 encodes an inductive signal for vulval development in C. elegans". Nature. 358 (6386): 470–6. doi:10.1038/358470a0. PMID 1641037.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Newman AP, White JG, Sternberg PW (1995). "The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell". Development. 121 (2): 263–71. PMID 7768171.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b Newman AP, White JG, Sternberg PW (1996). "Morphogenesis of the C. elegans hermaphrodite uterus". Development. 122 (11): 3617–26. PMID 8951077.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Sherwood DR, Sternberg PW (2003). "Anchor cell invasion into the vulval epithelium in C. elegans". Dev. Cell. 5 (1): 21–31. PMID 12852849.
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External links
Anchor cell page at Wormbase – part of the anatomy ontology of C. elegans.
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