Anchor cell

The anchor cell is a cell in nematodes such as Caenorhabditis elegans. It is important in the development of the reproductive system.

During the development of C. elegans hermaphrodites, the anchor cell produces a signalling molecule (LIN-3/EGF) that induces nearby epidermal cells to develop into the vulva.^[1] The anchor cell also produces another signal (the Notch ligand LAG-2) that induces adjacent uterine cells to become so-called π cells, which will connect the uterus to the vulva.^[2]

References

^ Hill RJ, Sternberg PW (1992). "The gene lin-3 encodes an inductive signal for vulval development in C. elegans". Nature. 358 (6386): 470–6. doi:10.1038/358470a0. PMID 1641037. {{cite journal}}: Unknown parameter |month= ignored (help)
^ Newman AP, White JG, Sternberg PW (1995). "The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell". Development. 121 (2): 263–71. PMID 7768171. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

External links

Anchor cell page at Wormbase – part of the anatomy ontology of C. elegans.

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[1] Hill RJ, Sternberg PW (1992). "The gene lin-3 encodes an inductive signal for vulval development in C. elegans". Nature. 358 (6386): 470–6. doi:10.1038/358470a0. PMID 1641037. {{cite journal}}: Unknown parameter |month= ignored (help)

[2] Newman AP, White JG, Sternberg PW (1995). "The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell". Development. 121 (2): 263–71. PMID 7768171. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

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