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The ob/ob or obese mouse is a mutant mouse that eats excessively and become profoundly obese. It is an animal model of type II diabetes. Identification of the gene mutated in ob led to the discovery of the hormone leptin, which is important in control of appetite.
The first ob/ob mouse arose by chance in a colony at the Jackson Laboratory in 1949.[1] Mutant mice are indistinguishable from their unaffected littermates at birth, but gain weight rapidly throughout their lives, reaching a weight three times that of unaffected mice. ob/ob mice develop high blood sugar, despite an enlargment of the pancreatic islets and increased levels of insulin.[2]
- ^ Ingalls AM, Dickie MM, Snell GD (1950). "Obese, a new mutation in the house mouse". J. Hered. 41 (12): 317–8. PMID 14824537.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Lindström P (2007). "The physiology of obese-hyperglycemic mice [ob/ob mice]". ScientificWorldJournal. 7: 666–85. doi:10.1100/tsw.2007.117. PMID 17619751.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
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